Correlation Between D-Dimer Level and Mortality Rate in Confirmed Coronavirus Disease 19 Adult Patients at Abdul Moeloek Hospital Bandar Lampung
DOI:
https://doi.org/10.53089/medula.v14i4.1055Keywords:
Mortality Rate, Covid-19, D-Dimer LevelAbstract
Lampung is one of the regions with the highest Case Fatality Rate (CFR) in Indonesia, which was 7.7% on September 16, 2021. Several studies have shown that D-Dimer levels influenced the mortality of confirmed Covid-19 patients. This study aimed to analyze the correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 adult patients. This research was an observational analytic study using a cross-sectional approach. The population of this study was all confirmed covid-19 adult patients who fulfilled the inclusion and exclusion criteria in Abdul Moeloek Hospital Medical Record Installation from 2020 to 2021. The samples were taken using simple random technique. Data collected were D-Dimer level, mortality rate, and patient’s personal information. Data were analyzed by Chi-Square using statistical data processing program. There were 94 subjects admitted in our study, divided into groups of survivors and non-survivors. From the non-survivors’ group, 43 (91%) subjects had a high D-Dimer level. The Chi-Square analysis showed a correlation between D-Dimer levels and the mortality rate of Covid-19 patients (p-value = 0,001). Statistically, there was a significant correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 patients.
References
Gorbalenya, A.E., Baker, S.C., Baric, R.S., Groot, R.J. de, Drosten, C., Gulyaeva, A.A., et al. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nature Microbiology. 2020; 5(4):536–44. https://doi.org/10.1038/s41564-020-0695-z.
ECDC. Cluster of pneumonia cases caused by a novel coronavirus, Wuhan,China. European Centre for Disease Prevention and Control. 2020.
Zarocostas, J. What next for the coronavirus response? The Lancet. 2020. Vol. 395. Elsevier Ltd. https://doi.org/10.1016/S0140-6736(20)30292-0.
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine. 2020; 382(8):727–33. https://doi.org/10.1056/nejmoa2001017.
Ge, H., Wang, X., Yuan, X., Xiao, G., Wang, C., Deng, T., et al. The epidemiology and clinical information about COVID-19. European Journal of Clinical Microbiology and Infectious Diseases. 2020;39(6):1011–19. https://doi.org/10.1007/s10096-020-03874-z.
Tanjung, M.S., Sitepu, R. Epidemiologi Deskriptif Coronavirus Disease 2019 (COVID-19) di Indonesia pada Tahun 2020. 2021; 20(2):179–91.
Satgas Covid-19. 2021. No Title. 2021. https://covid19.go.id/peta-sebaran-covid19.
WHO. Coronavirus (COVID-19) Overview. 2021. https://covid19.who.int/.
Gunardi, W.D. Pemeriksaan Diagnosis Laboratorium COVID-19 : Keterbatasan dan Tantangannya Saat Ini Laboratory Diagnostic Tests for COVID-19 : Current Limitations and Challenges 2019; 27(2):173–82.
Pusparini, P. Tes serologi dan polimerase chain reaction (PCR) untuk deteksi SARS-CoV-2/COVID-19. Jurnal Biomedika dan Kesehatan. 2020; 3(2):46–48. https://doi.org/10.18051/jbiomedkes.2020.v3.46-48.
Tang, N., Li, D., Wang, X., Sun, Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis. 2020; 18(4):844–47. https://doi.org/10.1111/jth.14768.
Terpos, E., Ntanasis-Stathopoulos, I., Elalamy, I., Kastritis, E., Sergentanis, T.N., Politou, M., et al. Hematological findings and complications of COVID-19. American Journal of Hematology. 2020;95(7):834–47. https://doi.org/10.1002/ajh.25829.
Mus, R., Thaslifa, T., Abbas, M., Sunaidi, Y. Studi Literatur: Tinjauan Pemeriksaan Laboratorium pada Pasien COVID-19. Jurnal Kesehatan Vokasional. 2021; 5(4):242. https://doi.org/10.22146/jkesvo.58741.
Yu, H.H., Qin, C., Chen, M., Wang, W., Tian, D.S. D-dimer level is associated with the severity of COVID-19. Thrombosis Research. 2020; 195:219–25. https://doi.org/10.1016/j.thromres.2020.07.047.
Listyoko, A.S., Djajalaksana, S., Sugiri, Y.J. Analisis Fibrinogen dan D-Dimer pada Pasien Covid-19 Rawat Inap. 2021;8(2):172–78.
Permana, A., Yari, C.E., Aditya, A.K. Gambaran D-Dimer Dan Limfosit Pada Pasien Terkonfirmasi Covid-19 Di RS Haji Jakarta. Anakes : Jurnal Ilmiah Analis Kesehatan. 2021; 7(1):62–71. https://doi.org/10.37012/anakes.v7i1.523
Suhartono, R., Nugroho, N.T. Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis. Journal of Thrombosis and Haemostasis. 2020;18(7):1738–42. https://doi.org/10.1111/jth.14850.
Willim, H.A., Hardigaloeh, A.T., Supit, A.I., Handriyani. Koagulopati pada Coronavirus Disease -2019 (COVID-19): Tinjauan pustaka. Intisari Sains Medis. 2020; 11(3):749–56. https://doi.org/10.15562/ism.v11i3.766.
Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., et al. Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine. 2020; 382(18):1708–20. https://doi.org/10.1056/nejmoa2002032.
Huang, X., Wei, F., Hu, L., Wen, L., Chen, K. Epidemiology and clinical characteristics of COVID-19. Archives of Iranian Medicine. 2020;23(4):268–71. https://doi.org/10.34172/aim.2020.09.
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229):1054–62. https://doi.org/10.1016/S0140-6736(20)30566-3.
Wada, H., Matsumoto, T., Yamashita, Y. Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines. Journal of Intensive Care. 2014;2(1):1–8. https://doi.org/10.1186/2052-0492-2-15.
Alonso-Fernández, Alberto, et al. Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study. PLoS One. 2020;15(8):1-15. https://doi.org/10.1371/journal.pone.0238216
Khaedir, Y. Perspektif Sains Pandemi Covid-19: Pendekatan Aspek Virologi Dan Epidemiologi Klinik. Maarif. 2020; 15(1):40–59. https://doi.org/10.47651/mrf.v15i1.76.
Yang, Xiaobo, et al. Thrombocytopenia and its association with mortality in patients with COVID‐19. Journal of Thrombosis and Haemostasis. 2020;18(6): 1469-1472
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(10223):1–7. https://doi.org/10.1016/S0140-6736(20)30211-7
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