Laporan Kasus: Case Report: Primigravida as a Risk Factor for Preeclampsia


  • Dinni Istiqomah Medical Faculty, Lampung University
  • Faisal Abdul Aziz M Universitas Lampung
  • Poppy Monika Sari Universitas Lampung
  • Wanda Feranti Siregar Universitas Lampung
  • Zulfadli Zulfadli Bagian Obsteri dan Ginekologi, RSUD Dr. H. Abdul Moeloek



Fase laten memanjang, preeklampsia, primigravida


Hypertension in pregnancy (HDK) is one of the main causes of maternal death and is a significant cause of maternal and child morbidity. Preeclampsia is the presence of specific hypertension caused by pregnancy accompanied by disorders of other organ systems at a gestational age of more than 20 weeks. There are several risk factors for preeclampsia, namely nullipara (primigravida), age ≥ 40 years, BMI ≥ 35, family history of preeclampsia, multifetal pregnancy and pregnancy interval > 10 years. This study is a case report. Data was obtained from a 22 year old woman who came with complaints of being at term pregnant with complaints of heartburn accompanied by headaches, shortness of breath, nausea and vomiting since 3 weeks  before hospital admission. The patient has suffered from hypertension since 7 months of pregnancy, but the patient does not regularly take medication. On physical examination, blood pressure was found to be 152/112 mmHg and urinalysis examination showed positive nitrite, protein 500 mg/dl. The patient was diagnosed with severe preeclampsia. Primigravida is the most important risk factor found in these patients. Several previous studies have shown that there is a relationship between primigravida and the incidence of preeclampsia, where preeclampsia occurs more often in primigravida than multigravida. There are various theories that explain the process of preeclampsia in primigravida, but no theory is considered absolutely correct to date. Therefore, intervention is needed for early prevention and early management of preeclampsia, especially in primigravida.


Kementerian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia Tahun 2018. Jakarta: Kementerian Kesehatan RI. 2019.

Roberts JM, August PA, Bakris G, Barton JR, Bernstein IM, Druzin ML, Gaiser RR, Granger JP, Jeyabalan A, Johnson DD, et al. Hypertension in pregnancy: report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122:1122–1131. doi: 10.1097/01.AOG.0000437382.03963.88.

ACOG Committee on Practice Bulletin, Gilstrap III, L.C., Ramin, S. Diagnosis and Management of Preeclampsia and Eclampsia. ACOG Practice Bulletin [Online], 2016. 33: 1-8. Available from

Perkumpulan Obstetri dan Ginekologi Indonesia. Pedoman Nasional Pelayanan Kedokteran: Diagnosis dan Tatalaksana Pre-Eklampsia. Jakarta: PB POGI. 2016.

Haslan H, Trisutrisno I. Dampak kejadian preeklampsia dalam kehamilan terhadap pertumbuhan janin intrauterin. Jurnal Ilmiah Kesehatan Sandi Husada. 2022. 11(2): 445-54.

Fox R, Kitt J, Leeson P, Aye CYL, Lewandowski AJ. Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring. J Clin Med. 2019. 4;8(10):1625. doi: 10.3390/jcm8101625. PMID: 31590294; PMCID: PMC6832549.

Ferawati E, Kuswandi K, Karmila N. Impact of severe preeclampsia on the incidence Low-Birth-Weight Babies. Majalah Kedokteran Bandung (MKB). 2023. 55(4):227–231.

Arwan B, Sriyanti R. Relationship between Gravida Status, Age, BMI (Body Mass Index) and Preeclampsia. Andalas Obstetrics Anda Gynecology Journal. 2020. 1: 1-21.

Vincent NTF, Darmayasa IM, Suardika A. Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017. Intisari Sains Medis. 2018. 9(2): 131-136.

Harumi AM, Armadani DK. Hubungan primigravida dengan kejadian preeklampsia pada ibu hamil di Puskesmas Jagir Surabaya. Midwifery Journal. 2019. 4(2): 79-82.

Meazaw MW, Chojenta C, Muluneh MD, Loxton D. Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa. PLoS One. 2020.19;15(8):e0237600. doi: 10.1371/journal.pone.0237600. PMID: 32813750; PMCID: PMC7437916.

Cunningham, F. G., Leveno, K. J., Bloom, S. L., Hauth, J. C., Gilstrap, L., & Wenstrom, K. D. Pregnancy Hypertension. Dalam F. G. Cunningham, K. J. Leveno, S. L. Bloom, J. C. Hauth, L. Gilstrap, & K. D. Wenstrom (Penyunt.), Williams Obstetrics (24th Edition ed.). New York: The McGraw-Hill Companies. 2014.

Rahmadhayanti, E., Hayati, L.and Saleh, M. I. Hubungan Polimorfisme Gen Reseptor Angiotensin II Tipe 1 1166 A / C Dengan Kejadian Preeklampsia. Majalah Kedokteran Sriwijaya, 2014. 46(1), pp. 52–58. Available at:

Maynard SE, Karumanchi SA. Angiogenic Factors and Preeclampsia. Semin Nephrol. 2011. 31(1): 33–46.

Lee K, Brayboy L, Tripathi A. Pre-eclampsia: a Scoping Review of Risk Factors and Suggestions for Future Research Direction. Regen Eng Transl Med. 2022. 8(3):394-406. doi: 10.1007/s40883-021-00243-w. Epub 2022 May 10. PMID: 35571151; PMCID: PMC9090120.



How to Cite

Istiqomah, D., M, F. A. A. ., Sari, P. M. ., Siregar, W. F. ., & Zulfadli, Z. (2024). Laporan Kasus: Case Report: Primigravida as a Risk Factor for Preeclampsia. Medical Profession Journal of Lampung, 14(5), 847-851.