The Role of Pharmacological and Non-Pharmacological Therapies in the Management of Dry Eye Disease

Authors

  • Grety Sitanggang Medical Faculty, Lampung University
  • Rani Himayani
  • Rekha Nova Iyos
  • Hanna Mutiara

DOI:

https://doi.org/10.53089/medula.v14i11.1469

Keywords:

Comprehensive management, dry eye disease, inflammation, non-pharmacological therapy, pharmacological therapy

Abstract

Dry Eye Disease (DED) is a multifactorial disorder of the ocular surface characterized by tear system imbalance, inflammation, and tissue damage, often leading to discomfort, visual disturbances, and a decline in quality of life. Managing DED requires a holistic approach that integrates both pharmacological and non-pharmacological therapies to alleviate symptoms while addressing underlying causes. Pharmacological treatments, such as artificial tears, anti-inflammatory agents (corticosteroids and cyclosporine), diquafosol tetrasodium, and oral pilocarpine, aim to restore ocular surface homeostasis. Non pharmacological approaches, including punctal plugs, lifestyle modifications, intense pulsed light (IPL) therapy, and nutritional supplementation with vitamin D and omega-3, are increasingly recognized for their supportive role in treatment. A comprehensive understanding of these therapeutic strategies is expected to improve DED management, enhance patients' quality of life, and prevent further complications.

Author Biographies

Rani Himayani

 

 

Rekha Nova Iyos

 

 

Hanna Mutiara

 

 

References

Elvira W. Penyakit mata kering. Cermin Dunia Kedokteran. 2018;45(3):192–6.

Tsubota K, Pflugfelder SC, Liu Z, Baudouin C, Kim HM, Messmer EM, et al. Defining dry eye from a clinical perspective. Int J Mol Sci. 2020;21(23):1–24.

Rajagukguk C, Santoso AS, Basoeki S. Pengaruh kemoterapi terhadap sindroma mata kering menggunakan tes ferning okuler. Maj Kedokt FKUB. 2016;3(2).

Jogi R. Basic ophthalmology. 4th ed. New Delhi: Jaypee Brothers Medical Publishers; 2009.

Laudita L, Jessica MV, Lina KD, Anugrahsari S. Tatalaksana terkini pada mata kering akibat pengaruh obat-obatan. J Med Scientiae. 2023;2(1):66–73.

Zemanová M. Dry eyes disease: a review. Cesk Slov Oftalmol. 2020;77(3):107–19.

Craig J, Nichols K, Akpek E, Caffery B, Dua H, Joo C, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017;15(3):276–83.

Rolando M, Barabino S. Dry eye disease: what is the role of vitamin D? Int J Mol Sci. 2023;24(2).

Semp DA, Beeson D, Sheppard AL, Dutta D, Wolffsohn JS. Artificial tears: a systematic review. Clin Optom (Auckl). 2023;15:9–27.

Ling J, Chan BCL, Tsang MSM, Gao X, Leung PC, Lam CWK, et al. Current advances in mechanisms and treatment of dry eye disease: toward anti-inflammatory and immunomodulatory therapy and traditional Chinese medicine. Front Med. 2022.

Abidi A, Shukla P, Ahmad A. Lifitegrast: a novel drug for treatment of dry eye disease. J Pharmacol Pharmacother. 2016;7(4):194–8.

Haber SL, Benson V, Buckway CJ, Gonzales JM, Romanet D, Scholes B. Lifitegrast: a novel drug for patients with dry eye disease. Ther Adv Ophthalmol. 2019;11:1–8.

Iskandar F. Diquafosol tetrasodium: tatalaksana terkini untuk dry eye disease (DED)?. Cermin Dunia Kedokteran. 2020;47(7).

Lau OCF, Samarawickrama C, Skalicky SE. P2Y2 receptor agonists for the treatment of dry eye disease: a review. Clin Ophthalmol. 2014;8:327–34.

Felberg S, Dantas PEC, Sato EH. Oral pilocarpine for the treatment of dry eye in patients with Sjögren’s syndrome. Arq Bras Oftalmol. 2022;85(3):269–76.

Song JS, Woo IH, Eom Y, Kim HM. Five misconceptions related to punctal plugs in dry eye management. Eye Contact Lens. 2018;37(11).

Pac CP, Sánchez-González JM, Rocha-de-Lossada C, Mercea N, Ferrari F, Preda MA, et al. Intense pulsed light therapy for dry eye disease: analyzing temporal changes in tear film stability and ocular surface between IPL sessions. Healthcare (Basel). 2024;12(11).

Chen D, Xu D, Wu X, Wang J, Sheng S, Yu X, et al. The efficacy of bandage contact lens in relieving the aggravation of dry eye disease after complicated cataract or/and IOL surgery. BMC Ophthalmol. 2024;24(1).

Dyrek M, Partyka A, Małachowski A, Malinowski P, Błaszczak E, Kopczyńska U, et al. Dry eye disease – how our lifestyle choices can affect the disease. J Educ Health Sport. 2024.

Kawashima M, Sano K, Takechi S, Tsubota K. Impact of lifestyle intervention on dry eye disease in office workers: a randomized controlled trial. J Occup Health. 2018;60(4):281–8.

Published

2025-02-19

How to Cite

Sitanggang, G., Himayani, R., Iyos, R. N., & Mutiara, H. (2025). The Role of Pharmacological and Non-Pharmacological Therapies in the Management of Dry Eye Disease. Medical Profession Journal of Lampung, 14(11), 2071-2076. https://doi.org/10.53089/medula.v14i11.1469

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