A Case Report of Pancytopenia Secondary to Falciparum Malaria Infection

Authors

  • Luh Dina Yulita Medical Faculty Lampung University
  • Yusuf Aulia Rahman Medical Faculty Lampung University

Keywords:

Anopheles Sp, malaria, pancytopenia

Abstract

Malaria is a life-threatening infectious disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes or through blood transfusion. Malaria is an endemic disease that still remains a major health problem in the world. The authors report a case of 21-years old man who presented with intermittent fever and pancytopenia without any signs of spontaneous bleeding that had a history of travel to a malaria endemic area. The diagnosis of malaria is made through examination of peripheral blood morphology. These findings highlights the importance for clinicians to consider tropical malaria diagnosis in patients with acute infection and presented with pancytopenia. Management of this patient included administration of anti-malaria drugs, transfusion of PRC, enteral nutrition, adequate fluids administration, antibiotics in the condition of leukopenia, and administration of other symptomatic therapies. The clinical condition and laboratory findings gradually improved after six days of hospitality.

References

World Health Organization. Malaria [Internet]. WHO. 2019 [diakses pada 10 November 2019]. Tersedia dari: https://www.who.int/news-room/fact-sheets/detail/malaria

Pusat Data dan Informasi Kementerian Kesehatan RI. InfoDatin Malaria. Infodatin Malaria; 2016.

Dinas Kesehatan Provinsi Lampung. Profil Kesehatan Provinsi Lampung Tahun 2016. Teluk Betung: Dinkes Provinsi Lampung; 2016.

Kementrian Kesehatan Republik Indonesia. Buku Saku Malaria 2017. Jakarta: Subdit Malaria Direktorat P2PTVZ; 2017.

Harijanto PN, Nugriho H GC. Malaria: dari molekuler ke klinis. Edisi ke-2. Jakarta: EGC; 2008.

WHO. Guideline for The Treatment of Malaria. Edisi Ketiga. Geneva: WHO Publication; 2015.

Joel G Breman, MD D. Malaria: Epidemiology, prevention, and control [Internet]. UpToDate. 2018 [diakses pada 15 November 2019]. Tersedia dari: https://www.uptodate.com/contents/malaria-epidemiology-prevention-and-control

CDC. Malaria Biology [Internet]. CDC. 2018 [diakses pada 15 November 2019]. Tersedia dari: https://www.cdc.gov/malaria/about/biology/index.html

Daily J, Baron EL. Anemia in Malaria. Wolters Kluwer; 2018.

Perkins DJ, Were T, Davenport GC, Kempaiah P, Hittner JB, Ong’echa JM. Severe malarial anemia: Innate immunity and pathogenesis. Int J Biol Sci. 2011;7(9):1427–42.

Bakta IM. Anemia Hemolitik. Hematologi Klnik Ringkas. Jakarta: Penerbit Buku Kedokteran EGC; 2015.

Arnold DM, Cuker A. Approach to the adult with unexplained thrombocytopenia Approach to the adult with unexplained thrombocytopenia. Wolters Kluwer. 2019.

Siagian LRD, Asfirizal V, Toruan VDL, Hasanah N. Thrombocyte counts in malaria patients at East Kalimantan. IOP Conf Ser Earth Environ Sci. 2018;144(1):0–5.

Lampah DA, Yeo TW, Malloy M, Kenangalem E, Douglas NM, Ronaldo D, et al. Severe malarial thrombocytopenia: A risk factor for mortality in Papua, Indonesia. J Infect Dis. 2015;211(4):623–34.

Punnath K, Dayanand KK, Chandrashekar VN, Achur RN, Kakkilaya SB, Ghosh SK, et al. Association between Inflammatory Cytokine Levels and Thrombocytopenia during Plasmodium falciparum and P. vivax Infections in South-Western Coastal Region of India. Malar Res Treat.;2019:1–10.

Michael S. Gordon, John Nemunaitis, Ron Hoffman, Ronald L. Paquette, Craig Rosenfeld, Sheryl Manfreda, Randi Isaacs SDN. A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia. Am Soc Hematol. 1995;85(11):3066–76.

Coates D Thomas. Infectious causes of neutropenia. Wolters Kluwer [Internet]. 2018 [diakses pada 15 November 2019]. Tersedia dari: https://www.uptodate.com/contents/infectious-causes-of-neutropenia

Meshnick SR. Artemisinin: Mechanisms of action, resistance and toxicity. Int J Parasitol. 2002;32(13):1655–60.

Nosten F, White NJ. Artemisinin-based combination treatment of falciparum malaria. Am J Trop Med Hyg. 2007;77(SUPPL. 6):181–92.

Paul N.Harijanto. Malaria. Buku Ajar Ilmu Penyakit Dalam. Interna Publishing; 2014.

Taylor TE. Treatment of severe malaria. Wolters Kluwer. 2019;82(17):44–51.

Published

2021-04-30

How to Cite

Luh Dina Yulita, & Yusuf Aulia Rahman. (2021). A Case Report of Pancytopenia Secondary to Falciparum Malaria Infection . Medical Profession Journal of Lampung, 9(4), 651-657. Retrieved from http://journalofmedula.com/index.php/medula/article/view/230

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