Obstructive Sleep Apnea Syndrome


  • William Bahagia Medical Faculty Lampung University
  • Putu Ristyaning Ayu Medical Faculty Lampung University


Obstructive Sleep Apnea (OSA) is a disorder and part of a complex sleep disorder breathing syndrome. OSA symptoms often occur althought it difficults to detect. If OSA does not get good management, it will cause long-term health problems. OSA is a condition of periodic upper airway obstruction during sleep that causes the breath to stop intermittently, either completely (apnea) or partial (hypoapnea). This condition is occurring in the upper respiratory tract (mainly in the oropharynx) resulting in decreased air flow. OSA symptoms are classified into night symptoms and daytime symptoms. Recurrent episodes of apnea, intermittent hypoxia and sleep fragmentation may affect organ function, especially the central nervous system and cardiovascular system, resulting in changes in metabolic balance. The gold standard for diagnosis of OSA is through a night sleep check with Polysomnography / PSG). The index used to determine the degree of mild-bad OSA is the Apnea-Hypoapnea Index (AHI), which counts the number of obstructive events per hour during sleep and the results of cardiorespiratory monitoring. Management of OSA consists of surgical therapy and non-surgical therapy. Positive airway pressure (PAP) is known to be the gold standard therapy for OSA. This article is a literature study to discuss pathophysiology, risk factors, signs and symptoms, to the handling and prevention of OSA.


Purnamasari D. Buku Ajar Ilmu Penyakit Dalam. Edisi 6. Jakarta: Papdi; 2014. 2325 p.

Spicuzza L, Caruso D, Maria G Di. Obstructive sleep apnoea syndrome and its management. Sage J. 2015;273–85.

Ye L, Pien GW, Ratcliffe SJ, Bjo E, Arnardottir ES, Pack AI, et al. The different clinical faces of Obstructive Sleep Apnoea : a Cluster Analysis. Eur Respir J. 2014;1600–7.

Arnardottir ES, Bjornsdottir E, Olafsdottir KA, Benediktsdottir B, Gislason T. Obstructive sleep apnoea in the general population : highly prevalent but minimal symptoms. Eur Respir J [Internet]. 2015;194–202. Available from: http://dx.doi.org/10.1183/13993003.01148-2015

Cahyono A, Hermani B, Mangunkusumo E, Perdana RS. Hubungan Obstructive Sleep Apnea dengan Penyakit Sistem Kardiovaskuler. ORLI. 2011;41(1):37–45.

Franklin KA, Sahlin C, Stenlund H, Lindberg E. Sleep apnoea is a common occurrence in females. Eur Respir J. 2013;41(3):610–5.

Osman AM, Carter SG, Carberry JC, Eckert DJ. Obstructive sleep apnea : current perspectives. Dove Press. 2018;(10):21–34.

Setyaningrum SD. Hubungan Antara Fungsi Kognitif Dengan Riwayat Obstructive Sleep Apnea Syndrome (Osas) pada Pasien Pasca Stroke Iskemik Di Rsup Dr Kariadi. Universitas Diponegoro; 2017.

Bakker J, Campbell A, Neill A. Randomized Controlled Trial Comparing Flexible and Continuous Positive Airway Pressure Delivery : Effects on Compliance , Objective and Subjective Sleepiness and Vigilance. Pubmed. 2010;33(4):30–2.

Sasongko PV, Yunika K, Andhitara Y. Faktor-Faktor Yang Berhubungan dengan Terjadinya Obstructive Sleep Apnea Syndrome (Osas) pada Pasien Stroke Iskemik. J Kedokt Diponegoro. 2016;5(4):1461–71.



How to Cite

William Bahagia, & Putu Ristyaning Ayu. (2021). Obstructive Sleep Apnea Syndrome. Medical Profession Journal of Lampung, 9(4), 705-711. Retrieved from http://journalofmedula.com/index.php/medula/article/view/238