Potensi Isoflavon Genistein Sebagai Terapi Suportif Imunonutrisi Pada Pasien Kanker Payudara

Regina Triswara; Ahmad Farishal; Bintang Abadi Siregar

doi:10.53089/medula.v9i4.242

Authors

Regina Triswara Medical Faculty Lampung University
Ahmad Farishal Medical Faculty Lampung University
Bintang Abadi Siregar Medical Faculty Lampung University

DOI:

https://doi.org/10.53089/medula.v9i4.242

Keywords:

Breast Cancer, genistein, immunonutrition

Abstract

Breast cancer is a malignancy in breast cells that grow out of control with a variety of mechanisms and risk factors. Breast cancer can be started from the ducts or lobular breasts. Breast cancer has a high incidence and high mortality in the Asian region due to various things, especially the process of early detection and therapy. Prevention stage is preferred over surgical or chemotherapy therapy. The condition of breast cancer patients must have a strong and tough immune system to supply cancer cells so that the need for proper nutrition is very much needed. Soybeans are rich in isoflavones known as antioxidants, antibacterial and most recently have anticancer potential. Genistein isoflavones in soybeans will be more active after the fermentation process and show the potential of cancer cell inhibitors by changing the phase of carcinogenesis with hormone receptor pathways and Nf-Kb-Akt signaling. Genistein is also proven as an inhibitor of angiogenesis in cancer cells. Further clinical trials need to be carried out on safety and the right dosage to be applied as immunonutrition in breast cancer patients.

References

Ghoncheh M, Mahdavifar N, Darvishi E,Salehiniya H. Epidemiology, incidence and mortality of breast cancer in Asia. Asian Pacific J Cancer Prev. 2016;17:47-52.

Tzou KS. An Introduction to Breast Cancer: Biology, Pathology, and the Latest in Screening and Diagnostic Tools. Cancer Epidemiol Biomarkers Prev. 2012;5(3):5-6.

Kautzky-Willer A, Harreiter J, Pacini G. Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. Endocr Rev. 2016;37(3):278-316.

Kuligowski M, Pawłowska K, Jasińska-Kuligowska I, Nowak J. Isoflavone composition, polyphenols content and antioxidative activity of soybean seeds during tempeh fermentation. CYTA - J Food. 2017;15(1):27-33.

H.-Q. Li, Y. Luo, C.-H. Qiao. The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone. Mini-Reviews Med Chem. 2012;12(4):350-362.

Roche company. Breast cancer A guide for journalists on. 2018.

Chandrasekharan AA. Pharmacokinetics of Dietary Isoflavones. J Steroids Horm Sci. 2013;s12(01):4-11.

Anjani SI, Farishal A, Nisa K. Potensi Isoflavon Kedelai sebagai Terapi Tambahan Diare Akut pada Anak Potential of Soy Isoflavones as an Additional Therapy for Acute Diarrhea in Children. 2019;6:394-399.

Dimidi E, Cox SR, Rossi M, Whelan K. Fermented Foods : Definitions and Characteristics , Gastrointestinal Health and Disease. Nutrients. 2019;11(1806).

Fawwaz M, Natalisnawati A, Baits M. Determination of Isoflavon Aglicone in Extract of Soymilk and Tempeh. Ind J Teknol dan Manaj Agroindustri. 2017;6(3):152-158.

Sarkar F, Adsule S, Padhye S, Kulkarni S, Li Y. The Role of Genistein and Synthetic Derivatives of Isoflavone in Cancer Prevention and Therapy. Mini-Reviews Med Chem. 2006;6(4):401-407.

Bondesson M, Gustafsson JA. Does consuming isoflavones reduce or increase breast cancer risk? Genome Med. 2010;2(12):12-16.

Ravindranath MH, Muthugounder S, Presser N, Viswanathan S. Anticancer Therapeutic Potential of Soy Isoflavone, Genistein. 2014;(310).

Varinska L, Gal P, Mojzisova G, Mirossay L, Mojzis J. Soy and breast cancer: Focus on angiogenesis. Int J Mol Sci. 2015;16(5):11728-11749.

Paul B, Royston KJ, Li Y, et al. Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition. PLoS One. 2017;12(12):1-20.

Hadibrata E, Farishal A, Ali Z, Danarto R. Tamsulosin And Sodium Diclofenac as An Effective Therapy To Reduce Pain After Ureteral Stent Removal: A Prospective, Double Blinded Randomized Placebo Controlled Trial Study. J Iran Urol. 2020:1-16.

Paul B, Li Y, Tollefsbol TO. The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: Role in epigenetic regulation. Int J Mol Sci. 2018;19(6).

Uifălean A, Schneider S, Ionescu C, Lalk M, Iuga CA. Soy Isoflavones and Breast Cancer Cell Lines: Molecular Mechanisms and Future Perspectives. Molecules. 2015;21(1):E13.