Identification of Gram Negative Bacteria that Produce Extended Spectrum Beta-Lactamase (ESBL) from Patients Using Urinary Catheter In Dr. H. Abdul Moeloek General Hospital, Bandar Lampung

Authors

  • Revina Rifda Amelia Universitas Lampung
  • Reyhan Anjani Putri
  • Tri Umiana Soleha

DOI:

https://doi.org/10.53089/medula.v13i1.502

Keywords:

Extended Spectrum Beta-Lactamase, gram negative bacteria, urine catheter, patient room class III

Abstract

Urinary catheterization is an action to insert a catheter into the patient's bladder through the urethra used in the hospital. The use of urinary catheters increases the risk of urinary tract infections (UTI) by about 5% every day. The incidence of nosocomial infection is 3 times higher in class III inpatients. According to research bacteria found as a cause of urinary tract infections due to urine catheters have a high enough potential to become a bacterium inhibiting Extended Spectrum Beta-Lactamase (ESBL). ESBL is a mutated β-lactamase enzyme, causing an increase in the enzymatic activity of β-lactamase, so that this enzyme can hydrolyze third generation sefalosporins and aztreonam. To find out the existence of ESBL-producing gram-negative bacteria in the catheter user urine in class III inpatients Dr. H. Abdul Moloek. This study used a categorical descriptive method with a cross sectional approach. The sample in this study were 22 patients who used catheters in class III inpatient rooms. Then the samples were tested for culture, biochemical tests and Double Disc Synergy Test. The results of a study of 22 patients undergoing a culture test found 4 patients with ESBL-producing gram-negative bacteria, 3 Escherichia coli bacteria (75%) and 1 Pseudomonas aeruginosa bacterium (25%) %), from these results the most bacteria producing ESBL is Escherichia coli. The conclusion is the highest amount of ESBL-producing bacteria was Escherichia coli (75%).

References

Saint S, Meddings JA, Calfee D, Kowalski CP, Krein SL. 2009. Catheter-associated urinary tract infection and the medicare rule changes. Ann Intern Med.;150(12):877-84.

Indrawan D. 2015. Prevalensi Infeksi Saluran Kemih pada Pasien Pengguna Kateter yang Dirawat di Ruang Rawat Inap RSUD. Dr. H. Abdul Moeloek Bandar Lampung. (Skripsi). Fakultas Kedokteran Universitas Lampung.

Erhadestria S. 2017. Uji Kepekaan Bakteri yang Diisolasi dari Urin Pengguna Kateter Pasien Ruang Rawat Intensif RSUD Dr. H. Abdul Moeloek Bandar Lampung.(Skripsi). Fakultas Kedokteran Lampung.

Brooks G, Carroll K. Bakteriologi. Dalam: Jawetz., Melnick., Adelberg. 2012. Mikrobiologi Kedokteran Edisi 25. Jakarta: EGC. hlm: 362.

Dewi KF, 2010. Skrining bateri penghasil Extended spectrum beta lactamases (ESBLs) pada kasus infeksi saluran kemih terkait kateterisasi di RSUD Pandan Arang, Boyolali. (Skripsi). Fakultas Kedokteran Universitas Sebelas Maret Surakarta.

Paterson DL, Bonomo RA. 2005.Extended spectrum beta-lactamases: a clinical update. ClinMicrobiol Rev.;18(4):657-86.

Nathisuwan S, Burgess DS, Lewis II JS. 2001. Extended spectrum beta-lactamases: epidemiology, detection and treatment. Pharmacotherapy. ;21(8):920-8.

Winarto. 2009. Prevalensi kuman ESBL (Extended Spectrum Beta-lactamase) dari material darah di RSUP Dr. Kariadi tahun 2004-2005. Media Medika Indonesia.;43(5):260-7

Mayasari E, Siregar C, Kusumawati RL. 2013. Prevalence and Antimicrobial Susceptibility Pattern of Extended Spectrum Beta-Lactamase Producing Escheria coli and Klebsiella pneumoniase Isolated from Various Specimens on Instalasi Mikrobiologi Klinik RSUP H. Adam Malik Medan. 7th National symposium of Indonesia Antimicrobial Resistance Watch(IARW).

Anggraini D, Hasanah U, Savira M, D Fauzia, Irawan D, R Ruzza. 2018. Prevalensi dan Pola Sensitivitas Enterobacteriaceae Penghasil ESBL di RSUD Arifin Achmad PekanbaruJurnal Kedokteran Brawijaya 30(1) :27-42

Endriani R, Andrini F, Alfina D. 2010. Pola Resistensi Bakteri Penyebab InfeksiSaluran Kemih (ISK) terhadap Antibakteri di Pekanbaru. Pekanbaru: JurnalNatur Indonesia. 12(2): 130-135.

Pradhan NP, Bhat SM, Ghadage DP. 2014. Nosocomial Infections in The Medical ICU: A Retrospective Study Highlighting Their Prevalence, Mikrobiological Profile and Impact on ICU Stay and Mortality. Journal of The Association of Physicians of India. 62: 18-21.

Pajariu A. 2010. Infeksi oleh bakteri penghasil extended spectrum beta lactamase (ESBL) di RSUP Dr. Kariadi Semarang: faktor risiko terkait penggunaan antibiotik.Fakultas KedokteranUniversitas Diponegoro.

Lee DS, Lee CB, Lee SJ. 2010. Prevalence and Risk Factors for Extended Spectrum Beta-Lactamase-Producing Uropathogens in Patients with Urinary Tract Infection. Korean J Urol.;51:492-497.

Paterson, David L., Bonomo, Robert A. 2010. Extended Spectrum β-Lactamases : a Clinical Update. Clinical Microbiology Review vol 18. pp:657-686

Potron A, Poirel L, Nordmann P. 2015. Emerging broad-spectrum resistance in Pseudomonas aeruginosaand Acinetobacter baumannii: mechanisms and epidemiology. Int J Antimicrob Agents.45: 568-585.

Kos VN, McLaughlin RE, Gardner HA. 2016. Elucidation of mechanisms of ceftazidime resistance among clinicalisolates of Pseudomonas aeruginosa by using genomic data. Antimicrob Agents Chemother. 60: 3856-3861.

Published

2023-01-24

How to Cite

Amelia, R. R., Reyhan Anjani Putri, & Tri Umiana Soleha. (2023). Identification of Gram Negative Bacteria that Produce Extended Spectrum Beta-Lactamase (ESBL) from Patients Using Urinary Catheter In Dr. H. Abdul Moeloek General Hospital, Bandar Lampung. Medical Profession Journal of Lampung, 13(1), 1-7. https://doi.org/10.53089/medula.v13i1.502

Issue

Section

Artikel

Most read articles by the same author(s)

1 2 > >>