Diuretic Effect of Nigella sativa to Treat Hypertension


  • Fadila Rahayu




Diuretic, hypertension, nigella sativa


Hypertension is a condition of increased blood pressure that can cause damage to organs such as heart, blood vessels, kidneys and the central nervous system. Prevention and treatment of hypertension requires something with minimal side effects. Nowadays, herbal medicine are so popular because its contain antioxidant and etc that can be another choice to treat the disease. One of them is Nigella sativa. The main contents are thymoquinone and polyphenols. N. sativa seeds contain protein (26.7%), fat (28.5%), carbohydrates (24.9%), crude fiber (8.4%) and total ash (4.8%). The seeds also contain many vitamins and minerals such as Cu, P, Zn and Fe etc. The seeds contain carotene which the liver converts into vitamin A. The roots and shoots are reported to contain vanillic acid. The seeds are reported to contain fatty oils rich in unsaturated fatty acids, especially linoleic acid (50-60%), oleic acid (20%), eicodadienoic acid (3%) and dihomolinoleic acid (10%). Nigella sativa has a diuretic effect to make diuresis so this can make lower blood pressure in hypertensive condition. Moreover, Nigella sativa has another mechanism to make blood pressure lower in hypertensive condition.


Jaarin K, Foong WD, Yeoh MH, Kamarul ZYN, Qodriyah HMS, Azman A, Dkk. Mechanisms of the antihypertensive effects of Nigella sativa oil in L-NAME-induced hypertensive rats. CLINICS. 2015; 70(11): 751-57.

Ibrahim MA, Eraqi MM, Alfaiz FA. Therapeutic role of taurine as antioxidant in reducing hypertension risks in rats. Heliyon. 2020; 6(1): 1-9.

Mohtashami R, Amini, Huseini HF, Ghamarchehr, Sadeqhi Z, Hajiagaee R. Blood pressure lowering effect of nigellasativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013;27(12):1849-53.

Venkatachallam SKT, Pattekhan H, Divakar S, Kadimi US. Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide. J Food Sci Technol. 2010; 47: 598–605.

Leong XF, Mustafa MR, Jaarin K. Nigella sativa and its protective role in oxidative stress and hypertension. Evidence-Based Complementary and Alternative Medicine. 2013; 1-9.

Jaarin K, Foong WD, Yeoh MH, Kamarul ZYN, Qodriyah HMS, Abdul A, Dkk. Mechanisms of the antihypertensive effects of nigella sativa oil in L-Name-induced hypertensive rats. Clinics. 2015; 70(11): 751-7.

Pourbakhsh H, Taghiabadi E, Abnous K, Hariri AT, Hosseini SM, Hosseinzadeh H. Effect of nigella sativa fixed oil on ethanol toxicity in rats. Iran J Basic Med Sci. 2014; 17(12): 1020-31.

Durante W. Targeting heme oxygenase-1 in vascular disease. Curr Drug Targets. 2010; 11(12): 1504–16.

Srichaikul B, Supachai S, Gordon B, Sunthorn D, Saksurn J. Ancient thai medicinal formula, volume 5: the therapeutic and clinical drug eview extracted from ancient thai palm leaf manuscripts. Advan Natur Sci. 2012. 5(3): 11-2.

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed. 2013; 3(5): 337-52.

Nery SDS, Gomides IRS, Silva IGVD, Forjaz CLDM, Jr IDM, TinucciI T. Intra-arterial blood pressure response in hypertensive subject during low- and high-intensity resistance exercise. CLINICS. 2010; 65(3): 271-7.

Rastogi L, Feroz S, Pandey BN, Jagtap A, Mishra KP. Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L. Int J Radiat Biol. 2010;86:719–31.

Mehmood MH, Aziz N, Ghayur MN, Gilani AH. Pharmacological basis for the medicinal use of psyllium husk (Ispaghula) in constipation and diarrhea. Dig Dis Sci. 2011; 56: 1460-71.

Rodriguez JRM,Vargas GA, Glucio JAGD, Ocharan Hernández MEO, Martinez REM, Caballero MEH, et al. Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in wistar rats. J Pharm Res. 2013; 6: 709-13.

Toma CC, Olah NK, Vlase L, Mogoșan C, Mocan A. Comparative studies on polyphenolic composition, antioxidant and diuretic effects of nigella sativa l. (black cumin) and nigella damascena l. (lady-in-a-ist) seeds. Molecules. 2015; 20: 9560-74.

Asif M, Jabeen Q, Majid AMSA, Atif M. Diuretic activity of aqueous extract of nigella sativa in albino rats. Acta Poloniae Pharmaceutica-Drug Research. 2015; 72(1): 129-35.

Najmi A, Nasiruddin M, Khan RA, Haque SF. Indigenous herbal product nigella satuva proved effective as an antihypertensive in metabolic syndrome. Asian J Pharm Clin Res. 2013; 6(1): 61-4.



How to Cite

Fadila Rahayu. (2020). Diuretic Effect of Nigella sativa to Treat Hypertension. Medical Profession Journal of Lampung, 10(2), 217-221. https://doi.org/10.53089/medula.v10i2.58