Proper Management of Underweight and Anemia in Tuberculosis Patients Increases The Improvement Time During Two-Week Treatment Follow-Up

Authors

DOI:

https://doi.org/10.53089/medula.v14i5.991

Keywords:

tuberculosis, anemia, malnutrition

Abstract

Tuberculosis (TB) continues to be the leading cause of disease and mortality caused by chronic pulmonary infection. The World Health Organization (WHO) considers that one-third of the global population is infected with Mycobacterium tuberculosis (Mtb).  Mycobacterium tuberculosis infection results in persistent lung damage, which is characterized by ongoing inflammation that damages lung tissue. The patient additionally experienced a cough for almost one month, with clear mucous, absence of blood, and mild shortness of breath. Patients had decreases in body weight and loss of appetite for about three weeks. Night sweats appeared within one month. There was no specific complaint of gastrointestinal symptoms. The patient's nutritional management was focused primarily on oral intake, with a total daily consumption of 1690 kcal. The daily protein, carbohydrate, and fat consumption is divided into 42.45 grams of protein, 253.5 grams of carbohydrates, and 37.5 grams of fat. There was no history of food allergy from the patient, therefore we decided not to impose any dietary restrictions. The improvement in body weight was used to monitor the outcome of the nutritional intervention. Nutritional issues have emerged as a significant contributor to an increasing percentage of individuals with low hemoglobin (Hb), influencing TB-related morbidity. The most prevalent causes of anemia in tuberculosis are nutritional deficiencies and malabsorption as a result of appetite loss. Poor intake of food has also been linked to an increased risk of disseminated TB. To improve treatment outcomes, nutritional support should be provided in addition to tuberculosis medicine.

Author Biographies

Tetra Arya Saputra

 

 

Adityo Wibowo, Juntendo University

 

     

References

Ticlla MR, Hella J, Hiza H, Sasamalo M, Mhimbira F, Rutaihwa LK, et al. The Sputum microbiome in pulmonary tuberculosis and its association with disease manifestations: A Cross-sectional study. Front Microbiol. 2021;12:633396.

Gupta P, Singh P, Das A, Kumar R. Determinants of tuberculosis: an example of high tuberculosis burden in the Saharia tribe. Front Public Health. 2023;11:1226980.

Chhabra S, Kashyap A, Bhagat M, Mahajan R, Sethi S. Anemia and nutritional status in tuberculosis patients. Int J Appl Basic Med Res. 2021;11(4):226-30.

Dasaradhan T, Koneti J, Kalluru R, Gadde S, Cherukuri SP, Chikatimalla R. Tuberculosis-associated anemia: A narrative review. Cureus. 2022;14(8):e27746.

Gelaw Y, Getaneh Z, Melku M. Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis. Environ Health Prev Med. 2021;26(1):13.

Gil-Santana L, Cruz LAB, Arriaga MB, Miranda PFC, Fukutani KF, Silveira-Mattos PS, et al. Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy. Sci Rep. 2019;9(1):1381.

de Mendonça EB, Schmaltz CA, Sant'Anna FM, Vizzoni AG, Mendes-de-Almeida DP, de Oliveira RVC, et al. Anemia in tuberculosis cases: A biomarker of severity? PLoS One. 2021;16(2):e0245458.

Abaynew Y, Ali A, Taye G, Shenkut M. Prevalence and types of anemia among people with tuberculosis in Africa: a systematic review and meta-analysis. Sci Rep. 2023;13(1):5385.

Araújo-Pereira M, Krishnan S, Salgame P, Manabe YC, Hosseinipour MC, Bisson G, et al. Effect of the relationship between anaemia and systemic inflammation on the risk of incident tuberculosis and death in people with advanced HIV: a sub-analysis of the REMEMBER trial. EClinicalMedicine. 2023;60:102030.

Begum S, Latunde-Dada GO. Anemia of inflammation with an emphasis on chronic kidney disease. Nutrients. 2019; 11(10):2424.

Demitto FO, Araújo-Pereira M, Schmaltz CA, Sant'Anna FM, Arriaga MB, Andrade BB, et al. Impact of persistent anemia on systemic inflammation and tuberculosis outcomes in persons living with HIV. Front Immunol. 2020;11:588405.

Luo M, Liu M, Wu X, Wu Y, Yang H, Qin L, et al. Impact of anemia on prognosis in tuberculosis patients. Ann Transl Med. 2022;10(6):329.

Ibrahim MK, Zambruni M, Melby CL, Melby PC. Impact of childhood malnutrition on host defense and infection. Clin Microbiol Rev. 2017;30(4):919-71.

Carwile ME, Hochberg NS, Sinha P. Undernutrition is feeding the tuberculosis pandemic: A perspective. J Clin Tuberc Other Mycobact Dis. 2022;27:100311.

Gao Z, Liu Q, Deng Q, Kong L, Liu Y. Growth and anemia among children with tuberculosis infection at different sites in Southwest China. Front Pediatr. 2023;11:1188704.

Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Respir Rev. 2018;27(147):170077.

Wiciński M, Liczner G, Cadelski K, Kołnierzak T, Nowaczewska M, Malinowski B. Anemia of Chronic Diseases: Wider Diagnostics—Better Treatment? Nutrients. 2020; 12(6):1784.

Liu QX, Tang DY, Xiang X, He JQ. Associations between nutritional and immune status and clinicopathologic factors in patients with tuberculosis: A comprehensive analysis. Front Cell Infect Microbiol. 2022;12:1013751.

Published

2024-04-30

How to Cite

Saputra, T. A., & Wibowo, A. (2024). Proper Management of Underweight and Anemia in Tuberculosis Patients Increases The Improvement Time During Two-Week Treatment Follow-Up. Medical Profession Journal of Lampung, 14(5), 852-857. https://doi.org/10.53089/medula.v14i5.991

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Artikel