Effects of SARS-CoV-2 Virus on The Organs

Authors

  • Rani Himayani Fakultas Kedokteran Universitas Lampung
  • Helmi Ismunandar Fakultas Kedokteran Universitas Lampung
  • Aulia Khairunnisa Fakultas Kedokteran Universitas Lampung
  • Gayitri Humaera Fakultas Kedokteran Universitas Lampung
  • Meilisa Hidayah Putri Fakultas Kedokteran Universitas Lampung
  • Novi Jayanti Fakultas Kedokteran Universitas Lampung

DOI:

https://doi.org/10.53089/medula.v11i1.178

Keywords:

Kata kunci: Covid-19, Angiotensin-converting enzyme, Multiple Organ.

Abstract

In December 2019, an outbreak of viral pneumonia caused by a novel coronavirus (since named SARS-CoV-2) was identified in Wuhan, China. Within few months, this disease known as coronavirus disease 2019 (COVID-19) spread worldwide, causing a global health emergency. The classic routes for transmission of SARS-CoV-2 are airborne droplets and surface contamination. The clinical presentation of COVID-19 ranges from asymptomatic infection to severe respiratory failure, with fever, fatigue, and cough occurring in most cases. The pathophysiology of SARS-CoV-2 infection is complex, endotoxin and tumor necrosis factor (TNF-α) trigger the production of interleukin (IL)-6 and IL-8, which is followed by a cytokine storm. Moreover, SARS-CoV-2 binds to angiotensin-converting enzyme-2 (ACE2) receptors, which are widely distributed not only in the lung alveolar epithelial cells and nasopharyngeal and oral mucosa but also in the endothelium and vascular smooth muscle cells, in the brain, in the gut, and in peripheral organs such as the liver and kidneys. This suggests that the clinical spectrum of COVID-19 is not limited to local pneumonia, but rather represents a multisystem illness with involvement of different organs and potential for systemic complications.

 

Keywords:Covid-19, Angiotensin-converting enzyme, Multiple Organs.

References

Ceraolo C, Giorgi FM. Genomic Variance of The 2019-nCoV Coronavirus. J med virol 2020.

Zhou P, Yang X, Wang X, et al. a Pneumonia Outbreak Associated with a New Coronavirus of Probable Bat Origin. Nature; 2020: 270-273.

World Health Organization. Novel Coronavirus (Covid-19) Situation Report. Available from: https://www.who.int/ docs/default-source/coronavirus/situation-report/2021

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H et al. Genomic Characterisation And Epidemiology of 2019 Novel Coronavirus: Implications for Virus Origin and Receptor Binding. Lancet; 2020: 565-74.

Gao K, Wang R. Machine Intellegence Design of 2019-nCoV Drugs. bioRxiv. available from: https;//www.biorxiv.org/ content/10.1101./2020.01.30.927889v1.full.pdf+html,

Coronavirus disease 2019 (COVID-19) treatment guidelines. 2020. Available from: https://covid19treatmentguidelines.nih.gov

Patel B, Kress J, Hall J: Alternatives to invasive ventilation in the COVID-19 pandemic . JAMA. 2020.

Xu Z, Shi L, Wang Y, et al.: Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet; 2020: 8:420-422.

Copin M, Parmentier E, Duburcq T: Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med. 2020.

Hariri L, Hardin C: Covid-19, angiogenesis, and ARDS endotypes. N Engl J Med; 2020: 383:182-183.

Ackermann M, Verleden S, Kuehnel M, et al.: Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020: 383:120-128.

Marini J, Gattinoni L: Management of COVID-19 respiratory distress. JAMA. 2020.

Madjid M, Safavi-Naeini P, Solomon S, et al.: Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol. 2020.

Alberici F, Delbarba E, Manenti C, et al.: Management of patients on dialysis and with kidney transplantation during the SARS-CoV-2 (COVID-19) pandemic in Brescia, Italy. Kidney Int Rep; 2020: 5:580-585.

Han C, Duan C, Zhang S, et al.: Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes. Am J Gastroenterol. 2020: 115:916-923.

Vaduganathan M, Vardeny O, Michel T, et al.: Renin-angiotensin-aldosterone system. Inhibitors in patients with Covid-19. N Engl J Med. 2020: 382:1653-1659.

Spinato G, Fabbris C, Polesel J, et al.: Alterations in smell or taste in mildly symptomatic outpatients with SARS-CoV-2 infection. JAMA. 2020: 323:2089-2090.

Wu P, Duan F, Luo C, et al.: Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei province, China. JAMA Ophthalmol. 2020: 575-578.

Recalcati S: Cutaneous manifestations in COVID‐ 19: a first perspective . J Eur Acad Dermatol. 2020.

Pfefferbaum B, North C: Mental health and the Covid-19 pandemic . N Engl J Med. 2020.

Published

2021-04-18

How to Cite

Rani Himayani, Helmi Ismunandar, Aulia Khairunnisa, Gayitri Humaera, Meilisa Hidayah Putri, & Novi Jayanti. (2021). Effects of SARS-CoV-2 Virus on The Organs. Medical Profession Journal of Lampung, 11(1), 43-47. https://doi.org/10.53089/medula.v11i1.178

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