Curcumin and Inflammatory Bowel Disease

Authors

  • Stevani Febeline Unila
  • Winda Trijayanthi Utama Medical Faculty of Lampung University
  • Waluyo Rudiyanto Medical Faculty of Lampung University

Keywords:

Curcumin, Inflammatory Bowel Disease, cytokine

Abstract

Inflammatory Bowel Disease (IBD) is an inflammatory disease of the gastrointestinal tract. The exact cause of Inflammatory Bowel Disease is not yet known clearly. The diagnosis of inflammatory bowel disease is often delayed due to non-specific and intermittent symptoms. There are 2 types of IBD, namely Ulcerative Colitis and Crohn's Disease. Management of IBD can be done with drug therapy, surgery, or a combination of both. This therapy aims to reduce symptoms, improve quality of life, prevent disease recurrence and avoid complications. IBD treatment can occur over a long period of time, during which time it costs quite a bit and can cause various side effects that can be experienced by patients. Therefore, experts began to consider other alternative therapies that could be used, for example the use of curcumin compounds. Curcumin is the active pigment that gives turmeric its yellow color, a plant that belongs to the ginger family or Zingiberaceae and contains anti-inflammatory substances. The mechanism of action of curcumin is by suppressing activity of Nuclear Factor-Kappa B (NF-KB) and also plays a role in suppressing Interleukin-1 (IL-1), IL-6, IL-12, IL-17, and Tumor Necrosis Factor Alpha (TNF). -α), two major cytokines that play an important role in the regulation of the inflammatory response. Management of IBD can be done through the administration of drugs so that curcumin can be considered as one of the treatments for IBD.

References

Brumatti, LV., Marcuzzi, A., Tricarico, PM., Zanin, V., Girardelli, M., & Bianco, AM. Curcumin and inflammatory bowel disease: Potential andlimits of innovative treatments. In Molecules. 2014.

Danastri, IGA., & Putra, IBD. Inflammatory Bowel Disease. E-Jurnal Medika Udayaba. 2013. 2(1):1-29.

Goulart, RDA., Barbalho, SM., Lima, VM., Souza, GA., Matias, JN., Araújo, AC., et al. Effects of the Use of Curcumin on Ulcerative Colitis and Crohn’s Disease: A Systematic Review. In Journal of Medicinal Food. 2021.

Sairenji, T., Collins, KL., & Evans, DV. An Update on Inflammatory Bowel Disease. In Primary Care - Clinics in Office Practice. 2017.

Yosy, DS., & Salwan, H. Inflammatory Bowel Disease Pada Anak. Majalah Kedokteran. 2014.

Gupta, SC., Kismali, G., Aggarwal, BB. Curcumin, a component of turmeric: From farm to pharmacy. In BioFactors. 2013.

Pulungan, ASS. Aktivitas Antijamur Ekstrak Etanol Daun Kunyit (Curcuma longa LINN.) terhadap Jamur Candida albicans. BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan). 2017.

Kim, YS., Young, MR., Bobe, G., Colburn, NH., & Milner, JA. Bioactive food components, inflammatory targets, and cancer prevention. In Cancer Prevention Research. 2009.

Chandra, S., & Simadibrata, M. Management of Inflammatory Bowel Disease. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy. 2014. 15(2):111-113.

Mutiah, R. Evidence Based Kurkumin dari Tanaman Kunyit (Curcuma longa) sebagai Terapi Pengobatan Modern. Jurnal Farma Sains. 2015. 1(1):28-41.

Shapiro, JM., Subedi, S., & LeLeiko, NS. Inflammatory bowel disease. In Pediatrics in Review. 2016.

Flynn, S., & Eisenstein, S. Inflammatory Bowel Disease Presentation and Diagnosis. In Surgical Clinics of North America. 2019.

Higuchi, LM., & Bousvaros, A. Clinical Features and Diagnosis of Inflammatory Bowel Disease in Children and Adolescents. 2013.

Seyedian, SS., Nokhostin, F., & Malamir, MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. In Journal of medicine and life. 2019.

Zhang, YZ., & Li, YY. Inflammatory bowel disease: Pathogenesis. World Journal of Gastroenterology. 2014.

Khawar, B., Abbasi, MH., & Sheikh, N. A panoramic spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation. In European Journal of Medical Research. 2015.

Ali, T., Shakir, F., & Morton, J. Curcumin and Inflammatory Bowel Disease : Biological Mechanism and Clinical Implication. Digestion. 2012. 85:249-255.

Firmansyah, MA. Perkembangan Terkini Diagnosis dan Penatalaksanaan Imflammatory Bowel Disease. Cermin Dunia Kedokteran. 2013.

Puteri, FD. Efek Kurkumin Pada Kunyit sebagai Pengobatan Kanker Lambung. Jurnal Ilmiah Kesehatan Sansi Husada. 2020. 9(2):861-864.

Supriono, S., Pratomo, B., & Praja, DI. Pengaruh Kurkumin Terhadap Kadar NF-κB dan Derajat Fibrosis Hati pada Tikus Fibrosis Hati. Jurnal Penyakit Dalam Indonesia. 2019.

Published

2022-02-18

How to Cite

Febeline, S., Winda Trijayanthi Utama, & Waluyo Rudiyanto. (2022). Curcumin and Inflammatory Bowel Disease. Medical Profession Journal of Lampung, 11(4), 367-371. Retrieved from https://journalofmedula.com/index.php/medula/article/view/318

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