The Effect Of Intramuscular Intramuscular Injection Of Human Umbilical Cord Mesenchymal Stem Cell On Histopathological Description Of White Rats (Rattus Norvegicus) Liver With Aspirin Induction

Authors

  • Asyraf Vivaldi Wardoyo Universitas Lampung
  • Evi Kurniawati
  • Susianti Susianti
  • Hendri Busman

DOI:

https://doi.org/10.53089/medula.v12i1.406

Keywords:

Aspirin, Liver histopatology, Mesenchymal stem cells

Abstract

Excessive and uncontrolled use of aspirin can cause several complications and various damage to organs, including damage to the liver. Human umbilical mesenchymal stem cells are an important source for regeneration and repair of damaged tissue. The purpose of this research is to prove the effect of intramuscular injection of human umbilical cord mesenchymal stem cells on the histopathological picture of white rat (Rattus Norvegicus) Sprague Dawley strain induced by aspirin. this study was an experimental study with a post-test only control group design with 27 white rats Sprague Dawley strains (Rattus norvegicus) which were divided into three treatment groups. The control group (K) was given standard food and drinks for 42 days, P1 was given aspirin 200 mg / kgBB by oral administration for 14 days, P2 was given aspirin 200 mg / kgBB orally for 14 days and was given mesenchymal stem cell injection of human umbilical cord intramuscularly 0.75 mL on days 14 and 28. The data that was obtained were observed by Kruskal-Wallis Non-Parametric Test, obtained p=0,000 (p<0,05). The expected results obtained Ho were expected. The statistical results with Mann-Whitney test obtained are also find significant differences in each groups, but P1 with P2 (p=0,199) not gained significant differences. The conclusion of this research is there is an effect of intramuscular injection of human umbilical cord mesenchymal stem cells on the histopathological picture of white rat liver (Rattus Norvegicus) Sprague Dawley strain induced by aspirin.

Author Biographies

Asyraf Vivaldi Wardoyo, Universitas Lampung

 

 

Evi Kurniawati

 

 

Susianti Susianti

 

 

Hendri Busman

 

 

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Published

2022-07-30

How to Cite

Wardoyo, A. V., Kurniawati, E., Susianti, S., & Busman, H. (2022). The Effect Of Intramuscular Intramuscular Injection Of Human Umbilical Cord Mesenchymal Stem Cell On Histopathological Description Of White Rats (Rattus Norvegicus) Liver With Aspirin Induction. Medical Profession Journal of Lampung, 12(1), 88-94. https://doi.org/10.53089/medula.v12i1.406

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