The Effect Of Ethanol Extract Of Pearl Grass (Hedyotis Corymbosa L.) On Liver Histopathology In White Rats (Rattus norvegicus) Male Sprague dawley Strain Induced By Rifampicin And Isoniazid

Authors

  • Zeni Okta Wiyanti Medical Faculty, Lampung University
  • Ahmad Haydar Rusdiansyah
  • Susianti Susianti universitas lampung
  • Rasmi Zakiah Oktarlina universitas lampung

DOI:

https://doi.org/10.53089/medula.v13i3.521

Keywords:

antioxidants, liver histopathology, pearl grass, tuberculosis

Abstract

Rifampicin and isoniazid are the first line treatment of tuberculosis. Long term treatment has caused rifampicin and isoniazid to have hepatotoxic side effects on the liver. Pearl grass effect through mechanism as antioxidants. To determine the effect of ethanol extract of pearl grass on liver histopathology in white rats male Sprague dawley strain induced by rifampicin and isoniazid. This study used 30 rats divided into 5 groups, that control 1 (K1) given aquades, control 2 (K2) without giving pearl, treatments groups 1,2, and 3 given rifampicin and isoniazid 200 mg/kgBB orally followed by pearl grass ethanol extract at successive doses of 200 mg/kgBB, 400 mg/kgBB, 800 mg/kgBB for 14 days. On the 14th days, the rats was terminated and the liver of the rats was taken for microscopic preparation. The average liver damage score obtained was K1=198,16, K2=501,44 P1=501,2, P2=417,6, and P3=394,4. Data were tasted with Shapiro-Wilk followed by post hoc tamhane’s test and found a significant differences.

References

WHO (World Health Organization). 2018. Global tuberculosis report 2018. Switzerland.

Almeida DSPE, Palomino JC. 2011. Molecular basis and mechanisms of drug resistance in mycobacterium tuberculosis: Classical and New Drugs. J Antimicrob Chemother. 66(7): 1425.

Katzung BG, Masters SB, Trevor AJ. 2014. Farmakologi dasar dan klinik. Edisi 13 Jakarta: EGC.

Direktorat Bina Farmasi Komuitas dan Klinik, Ditjen Bina Kefarmasian dan Alat Kesehatan dan Departemen Kesehatan RI. 2014. Pharmaceutical care untuk penyakit hati. Jakarta: Departemen Kesehatan RI.

Tostmann A, Boeree MJ, Aarnoutse RE, Lange Wiel CMD, Ven AJAM, Dekhuijzen R. 2007. Antituberculosis drug-induced hepatotoxicity: concise up-to-date review. Journal of Gastroenterology and Hepatology. 23: 192-202.

Dalimartha S. 2015. Ramuan tradisional untuk pengobatan hepatitis. Jakarta: Penebar Swadaya.

United State Department of Agriculture (USDA). 2016. Oldenlandia corymbosa L. Diakses 18 Agustus 2019.http://plants.usda.gov/core/profile? symbol=OLCO.

Kumar GSJ, Krishna BRB, Kumar VG. 2010. Hepatoprotective and antioxidant activity of the alcoholic extract of ipomoea turpetnm against anti-tb drugs induced hepatotoxicity in rats. Journal of Advances in Drug Research. Vol.1 Issue.1. pp 10-19.

Ardiningsih P. 2010. Efek pemberian rumput laut (sargassum sp) terhadap kadar sgot dan sgpt ayam. [Skripsi]. Bogor: Institut Pertanian Bogor.

Adiyati PN. 2011. Ragam jenis ektoparasit pada hewan coba tikus putih (rattus norvegicus) galur sprague dawley. [Skripsi]. Bogor: Institut Pertanian Bogor.

Vernon AA. 2014. Rifamycin Antibiotics with a focus on newer agents. Dalam Rom NW dan Garar MS (penyunting). Edisi ke-2. Philadelphia: Lippincot Williams & Wilkins.

Kumar V, Abbas AK, Aster, JC. 2013. Robbin’s basic pathology. Philadelphia: Elsevier. hlm. 6-9.

Febriana MV. 2015. Pengaruh meniran (phyllanthus niruri linn) terhadap gambaran histopatologi hepar tikus putih (rattus norvegicus) jantan yang diinduksi obat anti tuberkulosis (rifampisin dan isoniazid). [Skripsi]. Lampung: Universitas Lampung.

Published

2023-03-07

How to Cite

Zeni Okta Wiyanti, Ahmad Haydar Rusdiansyah, Susianti, S., & Oktarlina, R. Z. . (2023). The Effect Of Ethanol Extract Of Pearl Grass (Hedyotis Corymbosa L.) On Liver Histopathology In White Rats (Rattus norvegicus) Male Sprague dawley Strain Induced By Rifampicin And Isoniazid. Medical Profession Journal of Lampung, 13(3), 379-386. https://doi.org/10.53089/medula.v13i3.521

Issue

Section

Artikel

Most read articles by the same author(s)

1 2 > >>