Skleritis dan Rheumatoid Arthritis


  • Karelin Cut Dithia
  • Putu Ristyaning Ayu Sangging
  • Rani Himayani



rheumatoid arthritis, skleritis, mechanism


Rheumatoid arthritis is the result of a chronic inflammatory process that involves the immune system. One of the antibodies that is often detected in RA and scleritis patients is rheumatoid factor (RF). RF are antibodies produced by the immune system to attack the body's own tissues, including joints and synovial membranes. Another part of the antibody effect that is cyclic anti-citrate antibody (Anti-CCP), is an antibody that recognizes citrulinating proteins in body tissues, namely certain protein modifications that occur in RA patients and are considered as important factors in the pathogenesis of this disease. Increased RF levels can occur in patients with RA as well as in patients with scleritis. Scleritis is an inflammatory condition of the sclera, which is the thick white layer that lines the front of the eyeball. The etiology or cause of scleritis is still not known with certainty, apart from uncertain etiology, there are factors that can increase the risk of developing scleritis, such as autoimmune diseases, infections, vascular disorders, trauma, and drugs. This literature review discusses the relationship between rheumatoid arthritis and scleritis.


Author Biographies

Karelin Cut Dithia



Putu Ristyaning Ayu Sangging



Rani Himayani




Akpek EK, Bunya VY, Saldanha IJ. Sjögren’s syndrome: more than just dry eye. Cornea. 2019;38(5):658.

McFadden SA, Dennis YT, Bowrey HE, et al. Integration of defocus by dual power Fresnel lenses inhibits myopia in the mammalian eye. Invest Ophthalmol Vis Sci. 2014;55(2):908-917.

Cocho L, Gonzalez-Gonzalez LA, Molina-Prat N, Doctor P, Sainz-de-la-Maza M, Foster CS. Scleritis in patients with granulomatosis with polyangiitis (Wegener). British Journal of Ophthalmology. 2016;100(8):1062-1065.

Soares Pinheiro FGDM, Santana Santos E, Barreto ÍDDC, et al. Mortality Predictors and Associated Factors in Patients in the Intensive Care Unit: A Cross-Sectional Study. Crit Care Res Pract. 2020;2020:5-10. doi:10.1155/2020/1483827

Liao Y, Wang J, Jaehnig EJ, Shi Z, Zhang B. WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs. Nucleic Acids Res. 2019;47(W1):W199-W205.

Kumar P, Sen R, Aggarwal S, Agarwal S, Rajnish RK. Reliability of Modified Harris Hip Score as a tool for outcome evaluation of Total Hip Replacements in Indian population. J Clin Orthop Trauma. 2019;10(1):128-130.

McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New England Journal of Medicine. 2011;365(23):2205-2219.

Wolfe F, Michaud K, Busch RE, et al. Polysymptomatic distress in patients with rheumatoid arthritis: understanding disproportionate response and its spectrum. Arthritis Care Res (Hoboken). 2014;66(10):1465-1471.

Okhravi N, Odufuwa B, McCluskey P, Lightman S. Scleritis. Surv Ophthalmol. 2005;50(4):351-363.

Palmou-Fontana N, Calvo-Río V, Martín-Varillas JL, et al. Golimumab in refractory uveitis associated to juvenile idiopathic arthritis: multicentre study of 7 cases and literature review. Clin Exp Rheumatol. 2018;36(4):652-657.



How to Cite

Dithia, K. C., Ayu Sangging, P. R., & Himayani, R. (2023). Skleritis dan Rheumatoid Arthritis. Medical Profession Journal of Lampung, 13(6), 969-973.




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