Next-Generation Sequencing As A Novel Solution For Diagnosing Multidrug-Resistance Tuberculosis


  • Winda Medical Faculty Lampung University
  • Mirza Junando
  • Ervina Damayanti



Mycobacterium tuberculosis, Multidrug Resistance Tuberculosis, Next-Generation Sequencing


Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB). Based on WHO, in 2022, new TB cases and TB-related deaths are expected to be 6.4 million and 1.6 million cases respectively with Indonesia in second place with the largest burden of TB in the world. The number of cases has increased by around 4.5% compared to the previous year. With timely diagnosis and treatment with first-line antibiotics for six months, most people who develop TB can be cured and further transmission of infection can be prevented. Conventional diagnostic methods take a long time to obtain results, causing delays in diagnosis and delay in therapy. Next-generation sequencing (NGS) technology, especially whole genome sequencing (WGS) for TB, offers the most comprehensive and fast approach for molecular-based DST so that TB therapy can be given earlier and more effectively.


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How to Cite

Winda, Junando, M., & Damayanti, E. (2023). Next-Generation Sequencing As A Novel Solution For Diagnosing Multidrug-Resistance Tuberculosis. Medical Profession Journal of Lampung, 13(4), 563-568.




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