Incident Adverse Drug Reaction Renal Tubular Acidosis of Ibuprofen Use as a Drugs Over the Counter

Authors

  • Ghina Nur Alifah Medical Faculty, Lampung University
  • Citra Yuliyanda Pardilawati
  • Evi Kurniawati
  • Asep Sukohar

DOI:

https://doi.org/10.53089/medula.v14i4.1061

Keywords:

Asidosis tubulus ginjal, ibuprofen, reaksi obat yang tidak diinginkan

Abstract

Ibuprofen is an analgesic drug that can be obtained easily by patients because it is an over the counter (OTC) drug.  Ibuprofen when used can risk the lives of patients who consume it incorrectly.  Ibuprofen is a drug that causes damage to the kidneys or is nephrotoxic.  In large doses ibuprofen has been reported to cause hypokalemia, rhabdomyolysis and renal tubular acidosis Article searches with data sources from either journals or books with keywords used to facilitate searches. Journal articles used through case reports collect case reports of renal tubular acidosis due to the use of ibuprofen. In some of the case reports found, the use of ibuprofen had exceeded the dose set for OTC treatment. Patients with an average age of 41 years and reports ranged in age from 33 years to 63 years. Female patients has dominated the reported cases. The use of ibuprofen that caused the adverse drug reaction event belongs to type C, which is Chronic for continuous and long-term use of the drug. Non-pharmacological therapy that can be done is diet by limiting acid-producing foods and increasing alkaline-producing foods. Handling carried out on patients can be in the form of fluid resuscitation, electrolyte replacement through alkaline therapy, and supportive therapy according to the patient's clinical condition. Alkaline therapy using NaHCO3 and KHCO3 can be a fluid replacement and correct acidosis and hypokalemia.

Author Biographies

Ghina Nur Alifah, Medical Faculty, Lampung University

 

 

Citra Yuliyanda Pardilawati

 

 

Evi Kurniawati

 

 

Asep Sukohar

 

 

References

Bichard L, Toh D. Ibuprofen-induced distal (type 1) renal tubular acidosis and hypokalaemia: the dangers of ibuprofen-codeine combination over-the-counter preparations. Internal Medicine Journal. 2017; 47, issue 6; 707-709.

Blackstock MJ, Lee A. Hypokalaemia and Renal Tubular Acidosis due to Abuse of Nurofen Plus. Case Rep Crit Care. 2012.

BPOM. Informatorium obat nasional Indonesia. Jakarta: Badan Pengawas Obat dan Makanan. 2017.

Charles F, Lacy L, Armstrong L, Morton P, Goldman Rp, Leonard L, Lance Rp. Drug Informatorium Hanbook 17th edition. Association American Pharmacist. 2009.

Chávez-Iñiguez JS, Espinosa-García F, Pacheco-Plascencia A, Andrade-Sierra J, Rubio-Reynoso R, García-García G. The Case | Severe hypokalemia and metabolic acidosis. Kidney Int. 2018 May;93(5):1255-1256.

Dang M.H, Wu S, Sia C. Ibuprofen-induced renal tubular acidosis- a rare cause of rhabdomyolysis: a case report. Oxford Medical Case Reports. 2016;

Ghimire A, Li D, Amin L. Ibuprofen-induced renal tubular acidosis: case report on a not-so-basic clinical conundrum. Canadian Journal of Kidney Health and Disease. 2023.

Li, B. G., Masters, S. B., & Trevor, A. J. Farmakologi dasar & klinik. Edisi 12. McGraw-Hill. 2012.

Li R, Hasan N, Amstrong L, Cockings J. Impaired consciousness, hypokalaemia and renal tubular acidosis in sustained Nurofen plus abuse. BMJ Case Report. 2019;12(11):1-4.

Mandal AKJ, Howarth H, Jordaan JAJ, Missouris CG. Ibuprofen-Induced Distal Renal Tubular Acidosis and Hyporeninemic Hypoaldosteronism: Enough NSAID. Mayo Clin Proc. 2020;(10):2296-2299

Moore N, Pollack C, Butkerait P. Adverse drug reaction and drug-drug interactions with over-the-counter NSAIDs. Dove Press Journal. 2015.

Mediansyah A., Rahmanisa S. Hubungan ibuprofen terhadap ulkus gaster. Juke Unila. 2017;6(1):6-10.

Palmer BF, Kelepouris E, Clegg DJ. Renal Tubular Acidosis and Management Strategies: A Narrative Review. Adv Ther. 2021;38(2):949-968.

Pathya A., Harun H. Asidosis tubular renal distal. Jurnal Human Care. 2020;5(1): 220-224.

Patil S, Subramany S, Patil S, Gurram P, Singh M, Krause M. Ibuprofen Abuse-A Case of Rhabdomyolysis, Hypokalemia, and Hypophosphatemia with Drug-Induced Mixed Renal Tubular Acidosis. Kidney Int Rep. 2018;3(5):1237-1238.

Putri E.A.L., Sukohar A., Damayanti E. Medication error pada tahap prescribing, transcribing, dispensing, dan administration. Journal of medula. 2023;13(4): 457-462.

Salter MD. Ibuprofen-Induced Hypokalemia and Distal Renal Tubular Acidosis: A Patient's Perceptions of Over-the-Counter Medications and Their Adverse Effects. Hindawi Publishing Corporation. 2013.

Thammineni N, Kathi PR, Sharma A, Jawed A. Ibuprofen Overuse Leading to Life-threatening Hypokalemia Associated with Renal Tubular Acidosis in Two Patients. Cureus. 2019;11(12).

Udaykumar, P. Medical Pharmacology : Seventh Edition. New Delhi : CBS Publisher & Distributors Pvt.Ltd. 2021.

Katzung BG. Vasodilators & the treatment of Angina Pectoris. Basic & Clinical Pharmacology. 2012 Jan 3:193.

Friedlingstein P, O'sullivan M, Jones MW, Andrew RM, Hauck J, Olsen A, Peters GP, Peters W, Pongratz J, Sitch S, Le Quéré C. Global carbon budget 2020. Earth System Science Data Discussions. 2020 Oct 2;2020:1-3.

Published

2024-04-21

How to Cite

Alifah, G. N. ., Pardilawati, C. Y., Kurniawati, E. ., & Sukohar, A. (2024). Incident Adverse Drug Reaction Renal Tubular Acidosis of Ibuprofen Use as a Drugs Over the Counter . Medical Profession Journal of Lampung, 14(4), 732-738. https://doi.org/10.53089/medula.v14i4.1061

Issue

Section

Artikel

Most read articles by the same author(s)

<< < 1 2