The Relation Between Central Obesity and Differential Count in Male With Obesity in Lampung University


  • Diva Iole Humaira
  • Khairun Nisa Berawi
  • Chicy WIdya Morfi



Central obesity, differential count, male


Obesity is a condition characterized by excessive accumulation of fat in the body. One form of obesity is central obesity which is characterized by the accumulation of fat, especially in the abdomen, and is more common in men. Central obesity has a stronger correlation with various diseases as a result of chronic inflammatory reactions that occur in adipose tissue. This ongoing inflammatory process will cause changes in various immunological parameters, one of which is leukocyte count. This study aims to determine the relationship between central obesity and leukocyte count in adult obese men.

This research uses a cross-sectional approach. 59 study subjects were consisting of 39 central obese men and 20 non-obese central men. Venous blood samples were used in the calculation of differential counts and calculated Manually by microscope. The results showed a significant association between central obesity with neutrophil (p= 0,01), monocyte (p= 0,031) and lymphocyte counts (p= 0,003) but eosinophils and basophils did not have a significant relationship (p= 0,106 and

p= 0,166).  There is a relationship between central obesity with neutrophil type counts, monocytes, and lymphocytes in adult males with central obesity but eosinophils and basophils have no relationship.


Maria P, Evagelia S. 2009. Obesity disease. Health Science Journal. 3(3): 132–38.

Misra A, Chowbey P, Makkar BM, Vikram NK, Wasir JS, Chadha D, et al. 2009. Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. JAPI. 57: 163-70.

Kelishadi R, Mirmoghtadaee P, Najafi H, Keikha M. 2015. Systematic review on the association of abdominal obesity in children and adolescents with cardio-metabolic risk factors. J Res Med Sci. 4(20): 294–307.

Hruby A, Hu FB. 2016. The epidemiology of obesity: a big picture. HHS Public Access. 33(7): 673–89.

Wardhana I, Wangko S. 2011. Interaksi antara makrofag dan jaringan adiposa pada obesitas. Jurnal Biomedik. 3(2):111-118.

Fakultas Kedokteran Universitas Kedokteran (FK Unila). 2017. Buku penuntun praktikum patologi klinik blok hematoimunologi. Bandar Lampung: FK Unila.hlm. 10-15.

Sudikno, Syarief H, Dwiriani C, Riyadi H. 2015. Faktor risiko overweight dan obese pada orang dewasa di Indonesia (analisis data riset kesehatan dasar 2013). Journal of The Indonesian Nutrition Association. 38(2): 91-104.

Cheong SM, Kandiah M, Chinna K, Chan YM, Saad HA. 2010. Prevalence of obesity and factors associated with it in a worksite setting in Malaysia. J Community Health. 35(6): 698-705.

Vuong J, Qiu Y, La M, Clarke G, Swinkels D, Cembrowski G. 2014. Reference intervals of complete blood count constituent are highly correlated to waist circumference: should obese patients have their own "normal values?". Am J Hematol. 89(7): 671-77.

Li Q, Yu HY, Chen M, Jiang F, Zhou J, Bao YQ. 2017. Waist circumference-dependent peripheral monocyte change after gliclazide treatment for chinese type 2 diabetic patients. Med Sci. 37(2): 204-09.

Ikeda Y, Hisakawa N, Ohguro T, Nishiuchi J, Kumon Y. 2016. Differential white blood cell count and metabolic syndrome in Japanese men. Atherosceloris. 252: 181-82.

Ryder E, Ewald M, Mosquera J, Fernandez E, Pedreanez A, Vargas R, et al. 2014. Association of obesity with leukocyte countin obese individuals without metabolic syndrome. Diabetes India. 2014: 197-204.

Patel PS, Buras ED, Balasubramanyam. 2012. The role of the immune system in obesity and insulin resistance. Journal of Obesity. 2013: 1-9.

Huisstede A, Cabezas M, Birnie E, Geijin G, Rudolphus A, Mannaerts G. 2013. Systemic inflammation and lung function impairment in morbidly obese subjects with the metabolic syndrome. Journal of obesity. 13: 1-8.

Jamshidi L, Seif A. 2017. Association between obesity, white blood cell and platelet count. Zahedan J Res Med Sci. 6(15): 593-601.

Babio N, Jurado N, Bullo M, Gonzalez M, Warnberg J, Sallaverria I. 2013. White blood cell counts as risk markers of developing metabolic syndrome and its components in the predimed study. Plos one. 8(3): 1-11.

Yoshimura A, Ohnishi S, Orito C, Kawahara Y, Takasaki H, Takeda H. 2015. Association of peripheral total and differential leukocyte counts with obesity related complications in young adults. Journal of Obesity. 4(8):15-25.



How to Cite

Humaira, D. I. ., Khairun Nisa Berawi, & Chicy WIdya Morfi. (2020). The Relation Between Central Obesity and Differential Count in Male With Obesity in Lampung University. Medical Profession Journal of Lampung, 10(1), 43-48.




Most read articles by the same author(s)