Association Between The Consumption Of Fluticasone Corticosteroid Inhaler and Exacerbation In Chronic Obstructive Pulmonary Disease Patients In Abdul Moeloek Hospital from 2015-2017

Authors

  • Natasya Aurum Alifia Zaini Fakultas Kedokteran Universitas Lampung
  • Novita Carolia FAKULTAS KEDOKTERAN UNIVERSITAS LAMPUNG
  • Anggraeni Janar Wulan FAKULTAS KEDOKTERAN UNIVERSITAS LAMPUNG

DOI:

https://doi.org/10.53089/medula.v10i3.169

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease with irreversible condition. One of the treatment
using fluticasone inhaled corticosteroids shows a significant improvement in lung function, reducing symptoms and
reducing exacerbations. The purpose of this study was to determine the relationship of fluticasone corticosteroid inhalation
with the incidence of exacerbations in COPD patients at Abdul Moeloek Regional Hospital in the period 2015-2017 Lampung
Province. This study was an observational study that used secondary data (medical records) of 102 patients who were
analyzed the type of the drug they used with the occurrence of exacerbations they experienced. The results of the analysis
in this study showed a significant correlation between the use of fluticasone inhaled corticosteroids and the exacerbations
in COPD patients at Abdul Moeloek Hospital in 2015-2017 with a p value of 0.049 (p <0.05).

 

References

Perhimpunan Dokter Paru Indonesia.

Penyakit Paru Obstruktif Kronik

(PPOK). Pedoman Diagnosis &

Penatalaksanaan di Indonesia.

Perhimpunan Dokter Paru Indonesia.

Barnett, Margaret. 2006. Chronic

Obstructive Pulmonary

Disease.Chichester : John Wiley & Sons,

Ltd.

Supriyadi, Megantara. 2013. Faktor

Genetik Penyakit Paru Obstuksi Kronik.

Jakarta: Majalah Kedokteran Universitas

Indonesia Vol 40 No 8.

Riyanto BS, Heni RW, Barmawi H. 2014.

Ilmu Penyakit Dalam. Jakarta : Internal

Publishing Jilid I edisi VI, hal 204.

Han MK, Lazarus SC. 2016.COPD: Clinical

Diagnosis and Management. In :

Broaddus, V.C, et al, (Eds.). Textbook of

Respiratory Medicine. Ed, 6th, Canada :

Elsevier Inc.

Williams, Dennis M., Bourdet, Sharya V.

Chronic Obstructive Pulmonary

Disease.In : DiPiro, J, et al, (Eds).

Pharmacotherapy A Pathophysiologic

Approach seventh edition. New York: Mc

Graw-Hill. pp. 528-550.

GOLD. 2015.Pocked Guide To COPD

Diagnosis, Management, and Prevention.

USA : Global Initiative for Chronic

Obstructive Lung Disease, Inc.

Siswandono dan Soekardjo B.2008.Kimia

Medisinal Edisi ke-2. Surabaya: Airlangga

University Press, hal 423-434.

Akkermans RP, Biermans M, Robberts B,

Ter GJ, Jacob A, Van WC et al. 2014.

COPD prognosis in relation to diagnostic

criteria for airflow obstruction in

smokers.Radboud University Medical

Center. European Respiratory Journal

(1): 54-63

Prazasta RP. 2015. Penilaian Tingkat

Risiko dan Faktor-faktor yang

Berhubungan dengan Penyakit Paru

Obstruktif Kronik pada Masyarakat

Binaan KPKM Buaran FKIK UIN Syarif

Hidayatullah Tahun 2015. Jakarta: UIN

Syarif Hidayatullah

Tashkin D, Strange C. 2018. Inhaled

corticosteroids for chronic obstructive

pulmonary disease: what is their role in

therapy. International Journal of COPD;

-2601

Calverley PM, Anderson JA, Celli B,

Ferguson GT, Jenkins C, Jones PW, et al.

Salmeterol and fluticasone

propionate and survival in chronic

obstructive pulmonary disease.N Engl J

Med 2007; 356:775–789.

Lukito DB, Permana p. 2017. Penyakit

Paru Obstruksi Kronis Eksaserbasi Akut.

Fakultas Kedokteran Universitas

Udayana.

Wan ES, DeMeo DL, Hersh CP, Shapiro

SD, Rosiello RA, Sama SR, et al. 2011.

Clinical predictors of frequent

exacerbations in subjects with severe

chronic obstructive pulmonary disease

(COPD). Respir Med;105(4):588- 594.

Sin DD, Paul Man SF, Marciniuk DD, Ford

G, FitzGerald M, Wong E et al. The effect

of fluticasone with or without salmeterol

on systemic biomarkers of inflammation

in Chronic Obstructive Pulmonary

Disease. Am J Respir Crit Care Med 2008;

:1207-1214

Yawn BP, Raphiou I, Hurley JS, Dalal AA.

The role of fluticasone

propionate/salmeterol combination therapy in preventing exacerbations of

COPD. International Journal Chronic

Obstruct Pulmonary Disease; 5: 165–178.

Martinez FJ, Hastie AT. Curtis JL, et al.

Association of sputum and blood

eosinophil concentrations with clinical

measures of COPD severity: an analysis of

the SPIROMICS cohort. Lancet Respir

Med; 5(12):956–967.

Lipson, Barnhart, Brealey, Brooks, Criner,

Day NC et al. 2018. Once-Daily SingleInhaler

Triple versus Dual Therapy in

Patients with COPD. The New England

Journal of Medicine 378:1671-1680

Dransfield, Bourbeau, Jones, Hanania,

Mahler, Vestboet al. 2013.Once-daily

inhaled fluticasone furoate and vilanterol

versus vilanterol only for prevention of

exacerbations of COPD: two replicate

double-blind, parallel-group, randomised

controlled trials. The Lancet Respiratory

Medicine;1(3), 210–223.

Verhoeven GT, Hegmans JP, Mulder PG,

Bogaard JM, Hoogsteden HC, Prins JB.

Effects of fluticasone propionate in

COPD patients with bronchial

hyperresponsiveness. Thorax. 57(8): 694–

Rycroft C, Heyes, Lanza, Karin. 2012.

Epidemiologgy of Chronic Obstructive

Pulmonary Disease: a Literature Review.

International Journal of Chronic

Obstructive Pulmonary Disease; 457.

Rahmatika A. 2009. Karakteristik

penderita penyakit paru obstruktif kronik

yang di rawat inap di RSUD Aceh Tamiang

tahun 2007-2008. Medan: Universitas

Sumatra Utara

Departemen Kesehatan R.I. Direktorat

Jenderal Pengendalian Penyakit dan

Penyehatan Lingkungan Direktorat

Pengendalian Penyakit menular. 2008.

Pengendalian Penyakit Paru Obstruktif

Kronik (PPOK).Departemen Kesehatan R.I.

Published

2020-12-28

How to Cite

Natasya Aurum Alifia Zaini, Novita Carolia, & Anggraeni Janar Wulan. (2020). Association Between The Consumption Of Fluticasone Corticosteroid Inhaler and Exacerbation In Chronic Obstructive Pulmonary Disease Patients In Abdul Moeloek Hospital from 2015-2017 . Medical Profession Journal of Lampung, 10(3), 526-532. https://doi.org/10.53089/medula.v10i3.169

Issue

Section

Artikel

Most read articles by the same author(s)

1 2 > >>