Case Report: Primary Amenorrhea


  • Nurul Islamy universitas lampung
  • Odi Wijaya universitas lampung
  • nur sazaro tudhur universitas lampung
  • Anggita Dwi Paramitha universitas lampung



primary amenorrhea


Amenorrhea is defined as the absence of menarche in females of reproductive age. Primary amenorrhea is defined as the failure to initiate menses by age 14 in the absence of secondary sexual characteristics or the absence of menarche by age 16 regardless of the presence of normal growth and development of secondary sexual characteristics. In contrast, secondary amenorrhea is defined as the cessation of previous menses for more than 6 months. The etiology of amenorrhea can be seen from its anatomical and functional stratified components. Compartment I is disorders of the uterus and patency (outflow tract), such as Asherman's Syndrome, Tuberculous Endometritis. Compartment II is a disorder of the ovaries such as Turner Syndrome. Compartment III is a disorder of the pituitary such as pituitary adenoma, Empty Sella Syntrome, Sheehan's syndrome. Compartment IV, namely disorders of the hypothalamus or central nervous system such as Hypothalamic Amenorrhea, namely deficiency of GnRH pulsatile secretion causing disruption of gonadotropin secretion, resulting in impaired follicular maturation and ovulation, in turn, hypothalamic amenorrhea will occur. Based on chromosomal analysis, the cause of primary amenorrhea in 45% of cases is due to gonadal dysgenesis, chromosomal abnormalities or muller duct agenesis.


Muliani, I Gusti A, Nyoman G, Yuliana, Mangku K. Tahap Pertumbuhan dan Perkembangan tanda tanda seks sekunder remaja SMPN 4 Bangli, Desa Pengotan, Kecamatan Bangli. Medicina. 2017;48(2) : 75-82

Prawirohardjo S. Ilmu Kandungan. Jakarta : PT. Bina Pustaka Sarwono Prawirohardjo. 2011.

Ramadhina. Karakteristik Pasien Amenore Primer di Poliklinik Imunoendokrinologi Reproduksi Rumah Sakit Cipto Mangun Kusumo 2014. Jakarta: Universitas Indonesia; 2015

Ranjani M, Kanaklata N, Guanvant K. Mullerian anomalies : a cause of primary amenorrhea. JRCOG. 2013; Vol.2(3) : 393-397

Klein, David A dan Merrily A. Amenorrhea : An Approach to Diagnosis and Management. Americant Family Physician. 2013; Vol.87(11) : 781-788

Keith L, Arthur F. Anatomi Berorientasi Klinis. Jakarta; Erlangga : 2002.

Hoffman BL, Schorge JO, Schaffer JI, Halvorson LM, Bradshaw KD, Cunningham FG, editors. Williams



How to Cite

Nurul Islamy, Odi Wijaya, tudhur, nur sazaro, & Anggita Dwi Paramitha. (2021). Case Report: Primary Amenorrhea. Medical Profession Journal of Lampung, 11(1), 191-195.




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