Hemostasis Disturbance and Covid-19


  • Archie Avicenna Muhammad UNILA
  • Putu Ristyaning Ayu Sangging universitas lampung
  • agustyas tjiptaningrum universitas lampung
  • Helmi Ismunandar universitas lampung




Covid-19, Hemostasis


Hemostasis is the process of spontaneous cessation of blood from damaged blood vessels or due to rupture or tearing of blood vessels. SARS-CoV2 or otherwise known as COVID-19 coronavirus is a single-stranded RNA virion, has 4 genera: alpha, beta, gamma and delta. Impaired hemostasis in COVID-19 is a combination of hypercoagulation and impaired fibrinolysis, contributing to the risk of thrombosis. Using a literature review study. This article was created by summarizing the sources of information obtained from 25 articles and international journals published in the 2012-2022 period and one book published by the Ministry of Health of the Republic of Indonesia. Covid-19 is a disease caused by SARS-CoV 2, which damages tissue microcirculation that starts in the lungs and spreads to other organs. Covid-19 affects blood hemostasis, downregulation of ACE-2 when the virus enters infected cells or hyperinduction of cytokine production, a large number of COVID-19 patients develop signs of hypercoagulability, thrombocytopenia, and hyperfibrinolysis. The formation of thrombotic complications. To see the disturbances in blood hemostasis, a test such as PT, aPTT, TT, fibrinogen, and D-dimer can be performed.


Aggarwal, M., Dass, J., & Mahapatra, M. (2020). Hemostatic Abnormalities in COVID-19: An Update. Indian Journal of Hematology and Blood Transfusion, 36(4), 616–26.

Asakura, H., & Ogawa, H. (2020). COVID 19 associated coagulopathy and disseminated intravascular coagulation. International Journal of Hematology, 113, 45–57.

Bareille, M., Hardy, M., Douxfils, J., Roullet, S., Lasne, D., Levy, J. H., . . . Mullier, F. (2021). Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review. Journal of Clinical Medicine, 10(8), 1-56.

Castelli, R., & Gidaro, A. (2020). Abnormal Hemostatic Parameters and Risk of Thromboembolism Among Patients With COVID-19 Infection. Journal of hematology, 9(1-2), 1-4.

Cevik, M., Kuppalli, K., Kindrachuk, J., & Peiris, M. (2020). Virology, transmission, and pathogenesis of SARS-CoV-2. BMJ, 371, 1-6.

Chang, J. C. (2021). COVID-19 Sepsis: Pathogenesis and Endothelial Molecular Mechanisms Based on “Two-Path Unifying Theory” of Hemostasis and Endotheliopathy Associated Vascular Microthrombotic Disease, and Proposed Therapeutic Approach with Antimicrothrombotic Therapy. Vascular Health and Risk Management, 2021(17), 273-98.

Durachim, A., & Astuti, D. (2018). Hemostasis. Jakarta: Kementrian kesehatan Republik Indonesia.

Hadid, T., Kafri, Z., & Al-Katib, A. (2021). Coagulation and anticoagulation in COVID-19. Blood Reviews, 47(2021), 1-11.

Hulshof, A.-M., Braeken, D. C., Ghossein-Doha, C., Santen, S. v., Sels, J.-W. E., Kuiper, G. J., . . . Henskens, Y. M. (2021). Hemostasis and fibrinolysis in COVID-19 survivors 6 months after intensive care unit discharge. Research and Practice in Thrombosis and Haemostasis, 5(6), 1-8.

Joly, B. S., Siguret, V., & Veyradier, A. (2020). Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19. Intensive Care Medicine, 46, 1603-6.

Kantarcioglu, B., Iqbal, O., Walenga, J. M., Lewis, B., Lewis, J., Carter, C. A., . . . Fareed, J. (2021). An Update on the Pathogenesis of COVID-19 and the Reportedly Rare Thrombotic Events Following Vaccination. Clinical and Applied Thrombosis/Hemostasis, 27, 1-14.

Kichloo, A., Dettloff, K., Aljadah, M., Albosta, M., Jamal, S., Singh, J., . . . Khan, M. Z. (2020). COVID-19 and Hypercoagulability:A Review. Clinical and Applied Thrombosis/Hemostasis, 26, 1-9.

Lazzaroni, M. G., Piantoni, S., Masneri, S., Garrafa, E., Martini, G., Tincani, A., . . . Franceschini, F. (2021). Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system. Blood Reviews, 46, 1-7.

Levy, J. H., Iba, T., Olson, L. B., Corey, K. M., Ghadimi, K., & Connors, J. M. (2021). COVID-19: Thrombosis, thromboinflammation, and anticoagulation considerations. International Journal of Laboratory Hematology, 43(Suppl 1), 29-35.

Makris, M. (2020). Staying updated on COVID-19: Social media to amplify science in thrombosis and hemostasis. Research and Practice in Thrombosis and Haemostasis, 4(5), 722-26.

Mancini, I., Baronciani, L., Artoni, A., Colpani, P., Biganzoli, M., Cozzi, G., . . . Peyvandi, F. (2020). The ADAMTS13-von Willebrand factor axis in COVID-19 patients. Journal of Thrombosis and Haemostasis, 19(2), 513-21.

Meijenfeldt, F. A., Havervall, S., Adelmeijer, J., Lundström, A., Rudberg, A.-S., Magnusson, M., . . . Lisman, T. (2021). Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality. Research and Practice in Thrombosis and Haemostasis, 5(1), 132-41.

Parasher, A. (2021). COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgraduate Medical Journal, 97, 312-320.

Peyvandi, F., Artoni, A., Novembrino, C., Aliberti, S., Panigada, M., Boscarino, M., . . . Tripodi, A. (2020). Hemostatic alterations in COVID-19. Haematologica, 106(5), 1472-75.

Rossi, G. A., Sacco, O., Mancino, E., Cristiani, L., & Midulla, F. (2020). Differences and similarities between SARS CoV and SARS CoV 2: spike receptor binding domain recognition and host cell infection with support of cellular serine proteases. Infection, 48, 665-69.

Sathler, P. C. (2020). Hemostatic abnormalities in COVID-19: A guided review. Anais da Academia Brasileira de Ciencias, 92(4), 1-16.

Thachil, J., Cushman, M., & Srivastava, A. (2020). A proposal for staging COVID-19 coagulopathy. Research and practice in thrombosis and haemostasis, 4(5), 731-36.

Ulanowska, M., & Olas, B. (2021). Modulation of Hemostasis in COVID-19; Blood Platelets May Be Important Pieces in the COVID-19 Puzzle. Pathogens, 10(3), 1-11.

Wool, G. D., & Miller, J. L. (2020). The Impact of COVID-19 Disease on Platelets and Coagulation. Pathobiology, 88(1), 15–27.

Yuki, K., Fujiogi, M., & Koutsogiannaki, S. (2020). COVID-19 pathophysiology: A review. Clinical Immunology, 215(2020), 1-7.



How to Cite

Avicenna Muhammad, A., Putu Ristyaning Ayu Sangging, agustyas tjiptaningrum, & Helmi Ismunandar. (2022). Hemostasis Disturbance and Covid-19. Medical Profession Journal of Lampung, 12(1), 14-25. https://doi.org/10.53089/medula.v12i1.369




Most read articles by the same author(s)

1 2 > >>