Potential Therapy Of Diet Nutritional Supplements In Prevention Of Virus Diseases
DOI:
https://doi.org/10.53089/medula.v12i3.446Abstract
The tremendous increase in infections caused by viruses and their mortality rate has demanded producing effective and safe antiviral drugs. Symptomatic treatment and immune enhancement are the most efficient methods because no specific drugs are available for every viral disease. Several naturally occurring compounds available have demonstrated antiviral potential in preventing and debilitating viral diseases. A nutrient-rich diet can help reduce many viral infections. Nutrients such as vitamins (vitamins A, D, C, E, B6, and B12) and elemental groups provide the highest nutritional value for all body systems, including bones, cardiovascular, liver, skin, and support immunity. This research provides information on dietary-based scientific recommendations, evidence, and case studies worldwide concerning a particular focus on viral infections. In this study, the use of bioactive compounds in viral mechanisms, particularly SARS and respiratory viral infections, will be discussed, which may help in facilitating preintervention either directly as supplements/fortified foods or in combination with pharmaceutical drugs. This research method reviews the immune potential in the content of dietary supplements based on laboratory studies and human research through international journals, trusted websites, and books in the last ten years. The result is that bioactive compounds such as vitamins, elements, and minerals with proven antiviral properties, in addition to pharmaceutical drugs themselves as dietary supplements, have been shown to play an important role in treating various infections caused by viruses and strengthening the immune system.
References
Daftar Pustaka
Devaux, C. A., Rolain, J. M., & Raoult, D. ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome. Journal of microbiology, immunology, and infection. 2020; 53(3): 425–435. https://doi.org/10.1016/j.jmii.2020.04.015
McCarty, M. F., & DiNicolantonio, J. J. Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus. Progress in cardiovascular diseases. 2020; 63(3): 383–385. https: //doi.org/10.1016/j.pcad.2020.02.007
Lehtoranta, L., Pitkäranta, A., & Korpela, R. Probiotics in respiratory virus infections. European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology. 2014;33(8):1289–1302. https://doi.org/10.1007/s10096-014-2086-y
Jayawardena, R., Sooriyaarachchi, P., Chourdakis, M., Jeewandara, C., & Ranasinghe, P. (2020). Enhancing immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes & metabolic syndrome, 14(4), 367–382. https://doi.org/10.1016/j.dsx.2020.04.015
Wikefeldt, S. M. Flu Fighting Nutrition: Give Your Immune System a Boost. In Blog, Memorialcare; 2020. Diakses pada 18 April 2022 dari https://www.memorialcare.org/blog/flu-fighting-nutrition-give-your-immune-system-boost.
IFM. The Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents. Diakses pada 22 April 2022 dari https://www.ifm.org/newsinsights/the-functional-medicine-approach-to-covid-19-virus-specificnutraceutical-and-botanical-agents. Wanshington; 2022.
Martineau, A. R., Jolliffe, D. A., Greenberg, L., Aloia, J. F., Bergman, P., Dubnov-Raz, G., Esposito, S., Ganmaa, D., Ginde, A. A., Goodall, E. C., Grant, C. C., Janssens, W., Jensen, M. E., Kerley, C. P., Laaksi, I., Manaseki-Holland, S., Mauger, D., Murdoch, D. R., Neale, R., Rees, J. R., … Hooper, R. L. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health technology assessment (Winchester, England). 2019 ; 23(2): 1–44. https://doi.org/10.3310/hta23020
Yokoyama, S., Takahashi, S., Kawakami, Y., Hayes, C. N., Kohno, H., Kohno, H., Tsuji, K., Aisaka, Y., Kira, S., Yamashina, K., Nonaka, M., Moriya, T., Kitamoto, M., Aimitsu, S., Nakanishi, T., Kawakami, H., & Chayama, K. Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial. Journal of viral hepatitis. 2014; 21(5): 348–356. https://doi.org/10.1111/jvh.12146
Li JEvidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis. Critical care (London, England). 2018; 22(1): 258. https://doi.org/10.1186/s13054-018-2191-x
Fowler Iii, A. A., Kim, C., Lepler, L., Malhotra, R., Debesa, O., Natarajan, R., Fisher, B. J., Syed, A., DeWilde, C., Priday, A., & Kasirajan, V. Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome. World journal of critical care medicine. 2017; 6(1):85–90. https://doi.org/10.5492/wjccm.v6.i1.85
Peng, Z. Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia. ClinicalTrials.gov.Unite States; 2020. Diakses pada 25 April 2022 dari https://clinicaltrials.gov/ct2/show/NCT04264533.
Asthetics advisor. Can Quercetin, Vitamin C, Vitamin D and Zinc help Against Coronavirus? Diakses pada 15 Mei 2022 dari https://www.aestheticsadvisor.com/2020/03/can-quercetin-vitamin-c-vitamin-d-and-zinc-againstcovid19.html.
Hemilä, H., & Chalker, E. Vitamin C for preventing and treating the common cold. The Cochrane database of systematic reviews. 2013;(1), CD000980. https://doi.org/10.1002/14651858.CD000980.pub4
Meydani, S. N., Leka, L. S., Fine, B. C., Dallal, G. E., Keusch, G. T., Singh, M. F., & Hamer, D. H. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA. 2014;292(7): 828–836. https://doi.org/10.1001/jama.292.7.828
Fiorino, S., Bacchi-Reggiani, M. L., Leandri, P., Loggi, E., & Andreone, P. Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and meta-analysis. World journal of hepatology. 2017; 9(6): 333–342. https://doi.org/10.4254/wjh.v9.i6.333
Ragan, I., Hartson, L., Pidcoke, H., Bowen, R., & Goodrich, R. Pathogen reduction of SARS-CoV-2 virus in plasma and whole blood using riboflavin and UV light. PloS one 2020; 15(5), e0233947. https://doi.org/10.1371/journal.pone.0233947
Sheybani, Z., Dokoohaki, M. H., Negahdaripour, M., Dehdashti, M., Zolghadr, H., Moghadami, M., Masoompour, S. M., & Zolghadr, A. Role of Folic Acid in the Management of Respiratory Disease Caused by COVID-19. 2020. 10.26434/chemrxiv.12034980.
Shakoor, H., Feehan, J., Mikkelsen, K., Al Dhaheri, A. S., Ali, H. I., Platat, C., Ismail, L. C., Stojanovska, L., & Apostolopoulos, V. Be well: A potential role for vitamin B in COVID-19. Maturitas. 2021 ;144: 108–111. https://doi.org/10.1016/j.maturitas.2020.08.007
Sammy, M. Fight the Cold and FluWith These 6 Key Nutrients. Featured article. ; 2020. Diakses pada 6 April 2022, dari https://www.mdlinx.com/
Rerksuppaphol, S., & Rerksuppaphol, L. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children. Pediatric reports. 2019; 11(2): 7954. https://doi.org/10.4081/pr.2019.7954
Ishida, T. Review on The Role of Zn2+ Ions in Viral Pathogenesis and the Effect of Zn2+ Ions for Host Cell-Virus Growth Inhibition. American Journal of Biomedical Science & Research. 2019; 2: 28-37. 10.34297/AJBSR.2019.02.000566.
Barnett, J. B., Hamer, D. H., & Meydani, S. N. Low zinc status: a new risk factor for pneumonia in the elderly?. Nutrition reviews. 2010; 68(1) : 30–37. https://doi.org/10.1111/j.1753-4887.2009.00253.x
Skalny, A. V., Rink, L., Ajsuvakova, O. P., Aschner, M., Gritsenko, V. A., Alekseenko, S. I., Svistunov, A. A., Petrakis, D., Spandidos, D. A., Aaseth, J., Tsatsakis, A., & Tinkov, A. A. Zinc and respiratory tract infections: Perspectives for COVID 19 (Review). International journal of molecular medicine, 46(1), 17–26. https://doi.org/10.3892/ijmm.2020.4575
Derwand, R., Scholz, M., & Zelenko, V. COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study. International journal of antimicrobial agents. 2020; 56(6): 106214. https://doi.org/10.1016/j.ijantimicag.2020.106214
Collins, J. F., & Klevay, L. M. Copper. Advances in nutrition (Bethesda, Md.). 2011; 2(6):520–522. https://doi.org/10.3945/an.111.001222
van Doremalen, N., Bushmaker, T., Morris, D. H., Holbrook, M. G., Gamble, A., Williamson, B. N., Tamin, A., Harcourt, J. L., Thornburg, N. J., Gerber, S. I., Lloyd-Smith, J. O., de Wit, E., & Munster, V. J. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. The New England journal of medicine. 2020; 382(16): 1564–1567. https://doi.org/10.1056/NEJMc2004973
Erkekoğlu, P., Aşçı, A., Ceyhan, M., Kızılgün, M., Schweizer, U., Ataş, C., Kara, A., & Koçer Giray, B. Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children. The Turkish journal of paediatrics. 2013; 55(3): 271–282.
Sunde RA. Selenium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, editors.). Modern Nutrition in Health and Disease. 11th ed. Philadelphia, PA: LippincottWilliams &Wilkins; 2012.
Chaigne-Delalande, B., Li, F. Y., O'Connor, G. M., Lukacs, M. J., Jiang, P., Zheng, L., Shatzer, A., Biancalana, M., Pittaluga, S., Matthews, H. F., Jancel, T. J., Bleesing, J. J., Marsh, R. A., Kuijpers, T. W., Nichols, K. E., Lucas, C. L., Nagpal, S., Mehmet, H., Su, H. C., Cohen, J. I., … Lenardo, M. J. (2013). Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science (New York, N.Y.). 2013; 341(6142): 186–191. https://doi.org/10.1126/science.1240094
Singh, S., Kola, P., Kaur, D., Singla, G., Mishra, V., Panesar, P. S., Mallikarjunan, K., & Krishania, M. Therapeutic Potential of Nutraceuticals and Dietary Supplements in the Prevention of Viral Diseases: A Review. Frontiers in nutrition. 2021; 8: 679312. https://doi.org/10.3389/fnut.2021.679312
Baum, M. K., Campa, A., Lai, S., Sales Martinez, S., Tsalaile, L., Burns, P., Farahani, M., Li, Y., van Widenfelt, E., Page, J. B., Bussmann, H., Fawzi, W. W., Moyo, S., Makhema, J., Thior, I., Essex, M., & Marlink, R. Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naive, HIV-infected adults in Botswana: a randomized clinical trial. JAMA. 2013; 310(20): 2154–2163. https://doi.org/10.1001/jama.2013.280923
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