Review Article: Antibacterial Activity of Moringa Leaf Extract (Moringa oleifera L.) Against Staphylococcus aureus
DOI:
https://doi.org/10.53089/medula.v13i4.772Keywords:
Antibacterial, moringa leaves, Moringa oleifera L., Staphylococcus aureusAbstract
Infectious diseases are the main cause of high morbidity and mortality in developing countries. One of the therapies that can be used to treat infectious diseases is antibiotics. However, the irrational use of antibiotics can lead to the problem of antibiotic resistance. Therefore, it is necessary to find sources of natural drugs that have the potential as antibacterial agents. One of the medicinal plants is moringa (Moringa oleifera L.). Staphylococcus aureus is a normal human flora, but it can be pathogenic and cause infection in abnormal conditions. The severity of Staphylococcus aureus infection ranges from mild skin infection to severe necrotizing pneumonia. This article aims to determine whether moringa leaf extract (Moringa oleifera L.) can inhibit bacterial growth and what concentration of moringa leaf extract can provide the best antibacterial activity against Staphylococcus aureus. From the study results, it was known that moringa leaf extract (Moringa oleifera L.) proved to have good potential as an antibacterial, indicated by the presence of an inhibition zone formed. Moringa leaves (Moringa oleifera L.) contain phytochemicals such as tannins, steroids, terpenoids, flavonoids, saponins, anthraquinones, and alkaloids. These components are known to have strong potential as antibacterial agents with different mechanisms of action. Moringa leaf extract showed the best antibacterial activity against Staphylococcus aureus at a concentration of 75% with an inhibition zone diameter of 23 mm.
References
Oktaviani A, Muspiah A, Faturrahman. Aktivitas antibakteri dari ekstrak etanol Ganoderma sp. asal Pulau Lombok. J Sains Teknol Lingkung. 2020;6(1):22–8.
Fatimah S, Nadifah F, Burhanudin I. Uji daya hambat ekstrak etanol kubis (Brassica oleracea var. Capitata f. Alba) terhadap bakteri Staphylococcus aureus secara in vitro. Biog J Ilm Biol. 2016;4(2):102–6.
Arrang ST, Cokro F, Sianipar EA. Penggunaan antibiotika yang rasional pada masyarakat awam di Jakarta. J Mitra. 2019;3(1):73–82.
Abubakar I, Usman A. Phytochemical and antibacterial investigations of moringa (Moringa oleifera) leaf extract on selected bacterial pathogens. J Microbiol Antimicrob. 2016;8(5):28–33.
Savitri E, Fakhrurrazi, Harris A. Uji antibakteri ekstrak daun kelor (Moringa oleifera L.) terhadap pertumbuhan bakteri Staphylococcus aureus. J Ilm Mhs Vet. 2018;2(3):373–9.
Sudarwati D, Sumarni W. Uji aktivitas senyawa antibakteri pada ekstrak daun kelor dan bunga rosella. Indones J Chem Sci. 2016;5(1):1–4.
Gebregiorgis Amabye T, Tadesse FM. Phytochemical and antibacterial activity of Moringa oleifera available in the market of Mekelle. J Anal Pharm Res. 2016;2(1):1–4.
Tunas TH, Edy HJ, Siampa JP. Efek antibakteri ekstrak etanol daun kelor (Moringa oleifera Lam.) dan sediaan masker gel peel-off ekstrak etanol daun kelor (Moringa oleifera Lam.). J MIPA. 2019;8(3):112–5.
Bagheri G, Martorell M, Ramírez-Alarcón K, Salehi B, Sharifi-Rad J. Phytochemical screening of Moringa oleifera leaf extracts and their antimicrobial activities. Cell Mol Biol. 2020;66(1):20–6.
Agustie AWD, Samsumaharto RA. Uji aktivitas antibakteri ekstrak maserasi daun kelor (Moringa oleifera, Lamk) terhadap bakteri Staphylococcus aureus. Biomedika. 2013;6(2):14–9.
Onyekaba TU, Chinedu OG, Fred AC. Phytochemical screening and investigations of antibacterial activities of various fractions of the ethanol leaves extract of Moringa oleifera Lam (Moringaceae). J Pharm Chem Biol Sci [Internet]. 2013;3(3):962–73. Available from: www.ijpcbs.com
Widowati I, Efiyati S, Wahyuningtyas S. Uji aktivitas antibakteri ekstrak daun kelor (Moringa oleifera) terhadap bakteri pembusuk ikan segar (Pseudoonas aeruginosa). Pelita [Internet]. 2014;9(1):146–57. Available from: http://kelorina.com
Dima LLRH, Fatimawali, Lolo WA. Uji aktivitas antibakteri ekstrak daun kelor (Moringa oleifera L.) terhadap bakteri Escherichia coli dan Staphylococcus aureus. PHARMACON J Ilm Farm. 2016;5(2):282–9.
Oliveira D, Borges A, Simões M. Staphylococcus aureus toxins and their molecular activity in infectious diseases. Toxins (Basel). 2018;10(252):1–19.
Ahmad-Mansour N, Loubet P, Pouget C, Dunyach-Remy C, Sotto A. Staphylococcus aureus toxins: an update on their pathogenic properties and potential treatments. Toxins (Basel). 2021;13(677):1–22.
Karo MAB, Ferdinanda F, Natali O, Nasution SW. Uji efektivitas daun kelor terhadap Shigella dysenteriae. Biospecies. 2021;14(1):32–5.
Wulandari A, Farida Y, Taurhesia S. Perbandingan aktivitas ekstrak daun kelor dan teh hijau serta kombinasi sebagai antibakteri penyebab jerawat. J Fitofarmaka Indones. 2020;7(2):23–9.
Singh K, Tafida GM. Antibacterial activity of Moringa oleifera (Lam) leaves extracts against some selected bacteria. Int J Pharm Pharm Sci. 2014;6(9):52–4.
Egra S, Mardhiana, Rofin M, Adiwena M, Jannah N. Aktivitas antimikroba ekstrak bakau (Rhizophora mucronata) dalam menghambat pertumbuhan Ralstonia solanacearum penyebab penyakit layu. Agrovigor J Agroekoteknologi. 2019;12(1):26–31.
Noviyanty A, Salingkat CA, Syamsiar. Pengaruh jenis pelarut terhadap ekstraksi dari kulit buah naga merah (Hylocereus polyrhizus). KOVALEN J Ris Kim. 2019;5(3):271–9.
Khasanah N, Nawangsari D, Sunarti. Review: aktivitas antibakteri dari ekstrak biji mangga arumanis (Mangifera indica L. Var. Arumanis). J Dunia Farm. 2020;5(1):1–12.
Carolia N, Noventi W. Potensi ekstrak daun sirih hijau (Piper betle L.) sebagai alternatif terapi acne vulgaris. Majority. 2016;5(1):140–5.
Widhowati D, Musayannah BG, Nussa ORPA. Efek ekstrak bunga telang (Clitoria ternatea) sebagai anti bakteri alami terhadap pertumbuhan bakteri Staphylococcus aureus. VITEK Bid Kedokt Hewan. 2022;12(1):17–21.
Sapara TU, Waworuntu O, Juliatri. Efektivitas antibakteri ekstrak daun pacar air (Impatiens balsamina L.) terhadap pertumbuhan Porphyromonas gingivalis. PHARMACON J Ilm Farm. 2016;5(4):10–7.
Mayaserli DP, Shinta DY. Uji daya hambat dan daya bunuh ekstrak buah mengkudu (Morinda citrifolia Linn) terhadap pertumbuhan bakteri Staphylococcus aureus. J Kesehat Perintis (Perintis’s Heal Journal). 2021;8(1):67–74.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Medical Profession Journal of Lampung
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
