Comparison of the Effectiveness of ARB versus CCB Antihypertensive Drugs on Blood Pressure Reduction in Hypertensive Patients
DOI:
https://doi.org/10.53089/medula.v14i4.1047Keywords:
Angiotensin Receptor Blocker (ARB), Calcium Channel Blocker (CCB), HypertensionAbstract
Hypertension is defined as a systolic blood pressure of more than 140 mmHg and a diastolic blood pressure of more than 90 mmHg. Hypertension is a degenerative disease that requires long-term treatment. Hypertension is a silent killer disease because it does not cause symptoms and is only detected during physical examination due to certain diseases so that it can be a major cause of morbidity and mortality. Hypertension management guidelines recommend the use of thiazide/ACEi/ARB/CCB diuretic class drug monotherapy. The purpose of this study is to determine the difference in effectiveness between Calcium Channel Blocker (CCB) and Angiostensin Receptor Blocker (ARB) antihypertensives in reducing blood pressure. The method used in this study is through literature review using a database through Google Schoolar and Pubmed with a time span of 2013-2023 using the PICO method with keywords or keywords tailored to the search topic and articles selected based on inclusion criteria. The results of the literature show that ARB and CCB antihypertensives have similar effectiveness in lowering blood pressure. CCB antihypertensives are vasculoselective. This can be beneficial because CCBs are able to reduce peripheral resistance without reducing heart function so as to reduce the incidence of stroke. However, the use of CCBs can cause edema while ARBs have renoprotective effects or effects that protect the kidneys.
References
Ahadiah, N., Handayani, N., & Suhardiana, E. Evaluasi Kesesuaian Obat Dan Dosis Antihipertensi Di Instalasi Rawat Jalan Rumah Sakit “X” Kota Tasikmalaya. Media Informasi. 2020; 15(2): 129–137.
Gultom, R., & Silvia, M. Cost Minimalization Analysis (Cma) Penggunaan Obat Antihipertensi Golongan Calcium Channel Blocker Kombinasi Angiotensin Receptor Blocker Pada Pasien Hipertensi Di Rsu Imelda Pekerja Indonesia Medan. JIFI (Jurnal Ilmiah Farmasi Imelda). 2022; 5(2): 51–56.
Ma, J., Wang, X. Y., Hu, Z. De, Zhou, Z. R., Schoenhagen, P., & Wang, H. Meta-analysis of the efficacy and safety of adding an angiotensin receptor blocker (ARB) to a calcium channel blocker (CCB) following ineffective CCB monotherapy. Journal of Thoracic Disease. 2015; 7(12): 2243–2252.
Jm, W., Vm, M., Gill, R., Jm, W., Vm, M., & Gill, R. First-line drugs for hypertension. 2018,4:1-109.
Wu, L., Deng, S. B., & She, Q. Calcium Channel Blocker Compared With Angiotensin Receptor Blocker for Patients With Hypertension: A Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Hypertension. 2014; 16(11): 838–845.
Zhu, J., Chen, N., Zhou, M., Guo, J., Zhu, C., Zhou, J., Ma, M., & He, L. Calcium channel blockers versus other classes of drugs for hypertension. Cochrane Database of Systematic Reviews. 2022; 1:1-78
Hadiwiardjo, Y. H., Aprilia, C. A., & Citrawati, M. Perbandingan Efektivitas Penurunan Tekanan Darah Kombinasi Obat Angiotensin Receptor Blocker+Beta Blocker (ARB+BB) dan Calcium Channel Blocker+Beta Blocker (CCB+BB) Pasien Hypertensive Heart Disease (HHD). Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan. 2020; 5(1): 31–38.
Gultom, R. Evaluasi Pola Pengobatan Antihipertensi Golongan Calcium Channel Blocker (CCB) Kombinasi Angiotensin Receptor Blocker (ARB) Terhadap Pasien Hipertensi Di Ruang Rawat Inap Rumah Sakit Umum Imelda Pekerja Indonesia Medan. Jurnal Of Health and Medical Scince. 2022; 1(2):1–23.
Kinanti, W., Andayani, T. M., & Irijanto, F. Perbandingan Efektivitas Angiotensin Receptor Blocker (ARB) dengan Calcium Channel Blocker (CCB) Pada Pasien Penyakit Ginjal Kronis dengan Hemodialisis. JPSCR: Journal of Pharmaceutical Science and Clinical Research. 2022; 7(1): 28.
Fandinata, S. S., & Darmawan, R. Perbandingan Angiotensin II Receptor Blocker Candesartan vs Termisartan vs Valsartan pada Monitoring Tekanan Darah Pasien Chronic Kidney Disease. Jurnal Penelitian Kesehatan Suara Forikes. 2022; 13(1): 58–63.
Gangga, I. M. P., Wintariani, N. P., & Apsari, D. P. Pola Penggunaan Obat Antihipertensi Pasien Hipertensi Dan Hipertensi Dengan Diabetes Militus Di Puskesmas Selemadeg Timur II Tabanan. Widya Kesehatan. 2022; 4(2): 20–27.
Jeong, H. S., Lim, H. S., Park, H. J., Lee, W. S., & Choi, J. O. Clinical outcomes between calcium channel blockers and angiotensin receptor blockers in hypertensive patients without established cardiovascular diseases during a 3 ‑ year follow ‑ up. Nature Research. 2021; 11(1783): 1–10.
Lin, Y. C., Lin, J. W., Wu, M. S., Chen, K. C., Peng, C. C., & Kang, Y. N. Effects of calcium channel blockers comparing to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with hypertension and chronic kidney disease stage 3 to 5 and dialysis: A systematic review and meta-analysis. PLoS ONE. 2017; 12(12): 1–18.
Pahlawan, M. K., Astri, Y., & Saleh, I. Penggunaan Obat Antihipertensi pada Pasien Hipertensi di Bagian Rawat Jalan RS Muhammadiyah Palembang Periode Juli 2011–Juni 2012. Syifa’ MEDIKA: Jurnal Kedokteran Dan Kesehatan. 2013; 4(1): 22.
Sinnott, S. J., Douglas, I. J., Smeeth, L., Williamson, E., & Tomlinson, L. A. First line drug treatment for hypertension and reductions in blood pressure according to age and ethnicity: Cohort study in UK primary care. The BMJ. 2020; 371: 1–10.
Ulfa, N. M. Analisis Efektivitas Kontrol Penurunan Tekanan Darah pada Pasien Hipertensi yang Mendapat Terapi Obat Antihipertensi Golongan Angiotensin Receptor Blocker’s (Candersartan, Valsartan, Kalium Losartan). Journal of Pharmacy and Science. 2017; 2(2): 9–14.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Medical Profession Journal of Lampung
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
