Systematic Review: Relationship between Obesity and the Risk of Benign Prostate Hyperplasia
DOI:
https://doi.org/10.53089/medula.v14i2.978Abstract
Benign prostatic hyperplasia (BPH) is a non-malignant growth of prostate tissue. The incidence of BPH is influenced by various risk factors such as metabolic syndrome, obesity, and genetic predisposition. The prevalence of obesity in Indonesia with a male population over 18 years old was recorded at 26.60%. The research used a systematic review method. The databases used are NCBI and PUBMED with bulletions namely Benign prostate hyperplasia AND obesity, Benign prostate hyperplasia AND cholesterol, or Benign prostate hyperplasia AND body mass index. Obesity can trigger pro-inflammatory conditions, one of which is micro vascular disease which results in inflammation triggering ischemia and oxidative stress. Obesity can involve changes in the expression of genes such as A2M in the stroma and TFFB3 in the prostate gland and induce sIL-1ra levels.Obesity is associated with the risk of BPH through inflammatory response mechanisms from cellular and humoral microvascular inflammation, programmed cell death, gene expression and sIL-1ra levels.
References
Ayuningtyas, D., Kusuma, D., Amir, V., Tjandrarini, D. H., & Andarwati, P. Disparities in Obesity Rates among Adults: Analysis of 514 Districts in Indonesia. Nutrients. 2022; 14(16): 3332.
Badan Pusat Statistik. Prevalensi Obesitas pada Penduduk Umur >18 tahun Menurut Jenis Kelamin. 2018.
Batai, K., Phung, M., Bell, R., Lwin, A., Hynes, K. A., Price, E., Meiklejohn, K. M., Bracamonte, E. R., & Funk, J. T. Correlation between body mass index and prostate volume in benign prostatic hyperplasia patients undergoing holmium enucleation of the prostate surgery. BMC urology, 2021;21(1):88.
Ijaz Ur Rehmani, Syed Atif Hussain, Humayun Khan , Bilal Habib , Raheel Sheikh. The Association between obesity and prostate volume in patients with benign prostatic hyperplasia. PJMHS. 2021;15(6):1888-91.
Kementerian kesehatan RI.Panduan Pelaksaan Gerakan Nusantara Tekan Angka Obesitas (GENTAS). Jakarta: Direktorat Jenderal Pencegahan dan Pengendalian Penyakit Kementerian Kesehatan RI; 2017.
Khan, S., Wolin, K.Y., Pakpahan, R. et al. Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia. BMC Urol. 2021; 21: 47.
Lim K. B. 2017. Epidemiology of clinical benign prostatic hyperplasia. Asian journal of urology. 2017; 4(3): 148–151.
Lokeshwar, S. D., Harper, B. T., Webb, E., Jordan, A., Dykes, T. A., Neal, D. E., Jr, Terris, M. K., & Klaassen, Z. Epidemiology and treatment modalities for the management of benign prostatic hyperplasia. Translational andrology and urology. 2019; 8(5): 529–539.
Mampa, E., Haffejee, M. & Fru, P. Korelasi antara obesitas dan volume prostat pada pasien dengan hiperplasia prostat jinak di Rumah Sakit Akademik Charlotte Maxeke Johannesburg. Afr J Urol. 2021; 27:60.
Mochtar C.Panduan penatalaksanaan klinis pembesaran prostat jinak (benign prostatic hyperplasia/BPH). ikatan ahli urologi Indonesia. 2015
Ng, M., & Baradhi, K. M. Benign Prostatic Hyperplasia. In StatPearls. StatPearls Publishing. 2022.
Noweir, A., Abusamra, A., Al Zarooni, A., Binbay, M., Doble, A., Tariq, L., Aziz, F., & El Hasnaoui, A. Prevalence of benign prostatic hyperplasia among the adult general population of five Middle Eastern Countries: Results of the SNAPSHOT programme. Arab Journal of Urology. 2022; 20(1): 14–23.
Parikesit, D., Mochtar, C. A., Umbas, R., & Hamid, A. R. The impact of obesity towards prostate diseases. Prostate international. 2016; 4(1): 1–6.
Suarez Arbelaez, M. C., Nackeeran, S., Shah, K., Blachman-Braun, R., Bronson, I., Towe, M., Bhat, A., Marcovich, R., Ramasamy, R., & Shah, H. N. Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States. Annals of medicine. 2023; 55(1): 2197293.
Tyagi, P., Motley, S. S., Koyama, T., Kashyap, M., Gingrich, J., Yoshimura, N., & Fowke, J. H. Molecular correlates in urine for the obesity and prostatic inflammation of BPH/LUTS patients. The Prostate. 2018. 78(1): 17–24.
Wang, Y. B., Yang, L., Deng, Y. Q., Yan, S. Y., Luo, L. S., Chen, P., & Zeng, X. T. Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization stud. Journal of translational medicine. 2022; 20(1): 495.
Xiong Y, Zhang Y, Li X, dkk. Prevalensi dan faktor terkait gejala saluran kemih bagian bawah yang menunjukkan hiperplasia prostat jinak pada pria lanjut usia. Pria Penuaan. 2020; 20: 1-8.
Xiong Yang, Zhang Yangchang, Tan Jun, Qin Feng, dan Yuan Jiuhong. The association between metabolic syndrome and lowe urinary tract symptoms suggestive of benign prostatic hyperplasia in aging males: evidence based on propensity score matching. Translational andrology and urology. 2021;10:1.
Zhu, C., Wu, J., Wu, Y., Guo, W., Lu, J., Zhu, W., Li, X., Xu, N., & Zhang, Q. Triglyceride to high-density lipoprotein cholesterol ratio and total cholesterol to high-density lipoprotein cholesterol ratio and risk of benign prostatic hyperplasia in Chinese male subjects. Frontiers in nutrition. 2022; 9: 999995.
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