Effect Of Chitosan And Egg Shell Combination As A Bone Graft In Femur Fracture Management

Authors

  • Helmi Ismunandar

DOI:

https://doi.org/10.53089/medula.v10i2.53

Keywords:

Bonegraft, citosan, eggshell, fracture

Abstract

Fracture management affects the quality and quantity of osteogenic responses. Chitosan plays an important role in bone tissue engineering in the last two decades. Chicken eggshell contains apatite hydroxy, calcium, strontium, boron, zinc, copper, fluoride, magnesium, iron, and phosphorus which are needed in the process of bone healing. This is a comparative laboratory experimental research. There are 2 treatment groups. Rat’s right femur in both groups were fractured. There was no bone graft administration at  Group I, whereas there was bone graft administration at group II. The bone graft was combination of citosan and eggshell. Histological examination was performed at 5th week and It was assessed by Salkeld score. In group I, the mean Salkeld histological score was 0.4 ± 0.5. In group II the mean Salkeld histological score was 1.2 ± 0.8. Kalseld's histology score in group II was higher than the first group. Based on the Mann-Whitney examination, it can be concluded that there is a significant difference (p <0.035) in the bone healing process between group I and group II.

References

Chaidir MR. Interleukin-4 dan Interleukin-13 Sebagai Indikator Keberhasilan Tandur Tulang Kombinasi Cangkang Telur Ayam dan Platelet Rich Plasma Pada Defek Tulang Tibia Tikus. Disertasi. Bandung: Universitas Padjadjaran; 2013

Bashah DT, Dachew BA, Tiruneh BT. Prevalence Injury and Associated Factors Among Patients Visiting Emergency Departments of Amhara Regional State Referral Hospital, Ethiopia: a Cross-sectional Study. BMC Emergency Medicine. 2015; 15: 1-7

Edward BJ. The Burden of Musculoskeletal Disease in The United Stases [e-book]. Edisi 3. Rosemont: United States Boe and Joint Initiatiative; 2014 [diunduh 15 Mei 2017]. Tersedia di: www.boneandjointburden.org

Bulcholz RW, Heckman JD, Court-Brown CM, Tornetta P. Rockwood and Green’s Fractures in Adult. Edisi 7. Philadelphia: Lippincott Williams and Wilkins; 201:53-84

Trihono, Mboi N. Riset Kesehatan Dasar 2013. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. 2013; 100-9

Indonesia. Kementerian Kesehatan Indonesia. Profil Kesehatan Indonesia Tahun 2013. Jakarta: Kementerian Kesehatan Indonesia; 2014:3.

Keating JF, Simpson W, Robinson CM. The Management of Fracture With Bone Loss. The Journal of Bone and Joint Surgery. 2005; 87B (2): 143-150

Instalasi Rekam Medis RSUP Dr. Hasan Sadikin Bandung. Data Morbiditas Pasien RSHS tahun 2014 sampai 2016. Bandung; RSHS; 2016

Einhorn T, O’Keefe RJ, Buckwalter JA. Orthopaedic Basic Science Foundation of Clinical Practice. Edisi 3. USA: AAOS. 2007;65-87 331-49

Boden S, Greenwald S, Goldberg VM, Khan Y, Laurencin C. Bone Graft Subsitution: Facts, Fictions, and Aplication. 70th Annual Meeting of American Academy of Orthopaedic Surgeon; 2003 Februari 5-9; New Orleans, USA. Illinois; AAOS; 2003

Lan S. Citosan-based Scaffolds for Bone Tissue Engineering. J Mater Chem B Mater Biol Med. 2014; 2: 3161-84

Venkatesan J, Kim S. Citosan Composit for Bone Tissue Engineering. Journal of Marine Drug. 2010; 8: 2252-66

Kamala K, Sivaperumal P, Rajaram R. Extraction and Characterization of Water Soluble Citosan from Parapeneopsis Stylifera Shrimp Shell Waste and Its Antibacterial Activity. International Journal of Scientific and Research Publications. 2013; 3: 1-8

Published

2020-09-19

How to Cite

Helmi Ismunandar. (2020). Effect Of Chitosan And Egg Shell Combination As A Bone Graft In Femur Fracture Management. Medical Profession Journal of Lampung, 10(2), 193-196. https://doi.org/10.53089/medula.v10i2.53

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