Relationship Between the Incidence of Extra Pulmonary Tuberculosis with Lymphocyte and Monocyte Levels in RSUD Dr. H. Abdul Moeloek
DOI:
https://doi.org/10.53089/medula.v13i5.745Keywords:
lymphocytes, monocytes, extrapulmonary tuberculosisAbstract
Extra pulmonary tuberculosis (extra pulmonary TB) is a TB infection that attacks organs other than the lungs and is also a complication of TB. Adaptive immune response plays an important role in TB patients, one of which is the role of lymphocytes as antigen-antibody specificity and monocytes as phagocytosis of pathogens. The aim of this study was to determine the relationship between the incidence of extrapulmonary TB patients with lymphocyte and monocyte levels in RSUD dr. H. Abdul Moeloek Lampung Province. This research is a type of retrospective analytic observational study with a cross-sectional research design which was conducted in December 2020 levels in RSUD dr. H. Abdul Moeloek Lampung Province by looking at medical records for the period January 2018-December 2019. The sampling technique was consecutive sampling and calculated using the Slovin formula with a total sample of 103 patients. The analysis used is the chi square test. Central nervous system TB patients totaled 80 people who had lymphocytopenia 66 people (82.5%) and normal lymphocytes 14 people (17.5%), in TB lymphocytopenic patients there were 23 people who had lymphocytopenia 14 people (60.9%) and normal lymphocytes 9 people (39.1%). As for monocyte levels, there were 80 central nervous system TB patients with normal monocytes 50 people (62.5%) and monocytosis as many as 30 people (37.5%), in TB lymphadenitis patients there were 23 people with normal monocytes 12 people (52 .2%) and monocytosis in 11 people (47.8%). The results of the chi square test on lymphocyte levels with a value of p = 0.028 and monocyte levels with a value of p = 0.373, which means that there is a relationship between the incidence of extra pulmonary TB and lymphocyte levels and there is no relationship between the incidence of extra pulmonary TB and monocyte levels levels in RSUD dr. H. Abdul Moeloek Lampung Province.
References
Dotulong, Jendra FJ, Sapulete, Margareth R, Kandou, Grace D. Hubungan faktor risiko usia, jenis kelamin dan kepadatan hunian dengan kejadian penyakit TB Paru di Desa Wori Kecamatan Wori. Jurnal Kedokteran Komunitas dan Topik. . 2015 3(2): 57-65.
Kementerian Kesehatan Republik Indonesia. Pedoman nasional pelayanan kedokteran tata laksana tuberkulosis. Jakarta: Kementerian Kesehatan Republik Indonesia. 2016 : 62-83.
WHO. Global tuberculosis report. Geneva:WHO Press. 2017.
WHO. Global tuberculosis report. Geneva:WHO Press. 2019.
Kementerian Kesehatan Republik Indonesia. Situasi TBC di Indonesia [Internet]. 2019. Tersedia dari: https://www.tbindonesia.or.id/page/view/11/situasi-tbc-di- indonesia.
Kementerian Kesehatan Republik Indonesia. Situasi TBC di Indonesia [Internet]. 2019. Tersedia dari: https://www.tbindonesia.or.id/page/view/11/situasi-tbc-di- indonesia.
Rahman N, Pedersen KK, Rosenfeldt V, Johansen IS. Challenges in diagnosing tuberculosis in children. Dan Med J. 2012.59(7): A4463
Baratawidjaja KG, Rengganis I. Imunologi dasar. Edisi ke-10. Jakarta: FKUI. 2013. 222-33.
Mandal SK, Chavan L. Hematological profile in patients suffering from tuberculosis and treatment response. J Med Sci Clinic Res. 2016. 4.13146-50.
Davoudi S, Rasoolinegad M, Younesian M, Hajiabdolbaghi M, Soudbakhsh A, Jafari et al. CD4+ cell counts in patients with different clinical manifestations of tuberculosis. Braz J Infect Dis. 2008. 12(6): 483-6.
Ibrahim R, Setianegara B, Hermansyah H. Perbandingan nilai darah rutin dan berat badan anak pada pre dan post 2 bulan terapi OAT di Rumah Sakit Khusus Paru-Paru Palembang tahun 2013. Jurnal Kesehatan Poltekkes Palembang. 2014. 2(14): 1-10.
Alamlih L, Albakri M, Ibrahim WH, Khan A, Khan FY. Hematologic characteristics of patients with active pulmonary, extra-pulmonary and disseminated tuberculosis: A study of over six hundred patients. J Tubercle Res. 2020. 8(02): 33-41.
Sihombing JR, Ritonga AH. Pemeriksaan jumlah presentase sel monosit pada penderita tuberkulosis paru di UPT Kesehatan Provinsi Sumatera Utara. Jurnal Analis Laboratorium Medik. 2017. 2(1).
Azizi FH, Husin UA, Rusmartin T. 2014. Gambaran karakteristik tuberkulosis paru dan ekstra paru di BBKPM Bandung Tahun 2014. [disertasi]. Universitas Islam Bandung.
Thwaites G. Tuberculosis. Manson’s Tropical Diseases. 23rd edn. Elsevier. 2014. 468-505.
Suhariani W, Wibisono BH, Rachmawati B. 2015. Pola klinik tuberkulosis ekstra paru di RSUP Dr. Kariadi Semarang Periode Juli 2013-Agustus 2014.
Lin HH, Ezzati M, Chang HY, Murray M. Association between tobacco smoking and active tuberculosis in Taiwan: prospective cohort study. Am J Respir Crit Care Med. 2009. 180(5): 475-80.
Eisner M. Biology and mechanisms for tobacco-attributable respiratory diseases, including TB, bacterial pnemonia and other respiratory diseases. Intern J Tubercle Lung Dis. 2008. Volume 12.
Sadewo SW. Gambaran status anemia pada pasien tuberkulosis paru di unit pengobatan penyakit paru-paru Provinsi Kalimantan Barat tahun 2010-2012. [disertasi]. Kalimantan Barat. Universitas Tanjungpura. 2014.
Handojo WAA, Sudewi IGN, Budiarsa, Susilawathi NM. Karakteristik mortalitas pasien meningitis yang dirawat di RSUP Sanglah Denpasar bulan Juli 2013 – Juli 2014. Bagian/SMF Neurologi Fakultas Kedokteran Universitas Udayana/RSUP Sanglah Denpasar, Bali. [Thesis]. Bali. Universitas Udayana. 2014.
Price SA, Wilson LM. Patofisiologi: konsep klinis proses-proses penyakit. Edisi ke-6. Jakarta: EGC. 2012.
Rajasekaran S, Soundararajan DCR, Shetty AP, dan Kanna RM. Spinal tuberculosis: current concepts. Glob Spine J. 2018. 8(4S), 96S-108S.
Jniene A, Soualhi M, Bouassel M, Zahraoui R, Iraqi G. Epidemiological, therapeutic and evolutionary profiles in patients with lymph node tuberculosis. J Tuberk Toraks. 2010. 58(4): 366-74.
Sahal YP, Afgani A, Nilapsari R. Hubungan jumlah sel limfosit dengan usia dan status nutrisi pada penderita tuberkulosis. Global Med Health Communication. 2014. 2(2): 73−8.
Jones BE, Oo MM, Taikwel EK, Qian D, Kumar A, Maslow ER, et al. CD4 cell counts in human immunodeficiency virus—negative patients with tuberculosis. Clinical Infectious Diseases. 2012.24(5): 988-91.
Rizaldin V, Acang N, dan Santosa D. 2019. Karakteristik pasien TB paru dewasa di Rumah Sakit Al-Islam Bandung Tahun 2017. [disertasi]. Bandung. Universitas Islam Bandung.
Marbun CN. Gambaran jumlah monosit pada pasien tuberkulosis paru yang mendapat terapi obat anti tuberkulosis di RS Khusus Paru Provinsi Sumatera Selatan Tahun 2019. [skripsi]. Kementerian Kesehatan Repuublik Indonesia Politeknik Kesehatan Palembang Jurusan Analis Kesehatan. 2019.
Nugroho RA. Studi kualitatif faktor yang melatarbelakangi drop out pengobatan tuberkulosis paru. Jurnal Kesehatan Masyarakat, 2011. 7(1): 83-90
Kaihena, M. Propolis sebagai imunostimultor terhadap infeksi mycobacterium tuberculosis. Jurnal Fakultas MIPA Universitas Pattimura Ambon. 2013. 4(2): 69-80.
Lichtman MA, Williams WJ, Beutler E, Kaushansky K, Kipps TJ, Seligsohn U, et al. Monocytosis and monocytopenia. Williams Hematology New York, NY. McGraw Hill. 2005. 1(5):881-4.
Kumar V, Abbas AK, Aster JC. Robbins basic pathology e-book. Elsevier Health Science.2017.
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