Correlation Between Neutrophil Lymphocyte Ratio and Breast Cancer Stages Based On The Eighth Edition American Joint Committee On Cancer At Dr. H. Abdul Moeloek Hospital, Lampung Province
DOI:
https://doi.org/10.53089/medula.v13i7.865Keywords:
American Joint Committee on Cancer (AJCC), Breast cancer stage, neutrophil lymphocyte ratioAbstract
Breast cancer is a disease in which changes and uncontrolled cell growth occurs in breast tissue originating from the lobules or ducts. In breast cancer, neutrophilia can occur followed by lymphocytopenia which increases the neutrophil-lymphocyte ratio (NLR). Increased NLR has been associated with the development of cancer. This study aims to determine the correlation between neutrophil lymphocyte ratio and breast cancer stages based on the eighth edition American Joint Committee on Cancer at DR. H. Abdul Moeloek hospital, Lampung Province. This research methodology employed is descriptive analytical with a cross-sectional design. The sampling technique using a consecutive sampling technique. The data analysis used was the spearman correlation test. The results revealed that breast cancer patients were divided into two groups: early-stage and advanced-stage, with 22 patients (35.5%) in the early stage and 40 patients(64.5%) in the advanced stage. The median (minimum-maximum) NLR value of breast cancer patients was 3.17 (1.37-14.67). Statistical analysis showed a significant correlation between NLR and breast cancer stage, with a p-value of 0.004 and a correlation coefficient (r) of r = 0.357, which means that the direction of the correlation is positive with the strength of the correlation is weak. In conclution, there is a correlation between neutrophil lymphocyte ratio and breast cancer stages based on the eighth edition American Joint Committee on Cancer at DR. H. Abdul Moeloek hospital, Lampung Province.
References
American Cancer Society. Breast Cancer Facts & Figures 2019-2020. Atlanta: American Cancer Society Inc; 2019.
Globocan. Cancer today. International Agency for Research on Cancer[Internet]. France: International Agency for Research on Cancer: 2020 [disitasi tanggal 31 Desember 2020]. Tersedia dari: bit.ly/3qtjOfP.
Shaul ME, Fridlender ZG. Tumour-associated neutrophils in patients with cancer. Nature Reviews Clinical Oncology. 2019;16(10):601-20.
Howard R, Kanetsky PA, Egan, KM. Exploring the prognostic value of the neutrophil-to-lymphocyte ratio in cancer. Scientific Reports. 2019;9(1):1-10.
Chen J, Deng Q, Pan Y, He B, Ying H, Sun H, et al. Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer. FEBS Open Bio. 2015;5(1):502-7.
Prasetyo YE, Bahrun U, Pakasi RDN. Angka banding neutrofil/limfosit di karsinoma payudara. Indonesian Journal of Clinical Pathology and Medical Laboratory. 2015;21(2):125-9.
Elyasinia F, Yaghoubi M, Keramati MR, Ahmadi F, Rezaei S, Ashouri M, et al. Neutrophil-lymphocyte ratio in different stages of breast cancer. Acta Medica Iranica. 2017;55(4):228-32.
Juranah, Widaningsih Y, Hamdani W, Pakasi RDN, Bahrun U. Kadar interleukin-8 kanker payudara. Indonesian Journal of Clinical Pathology and Medical Laboratory. 2014;20(3):205-9.
Dahlan MS. Besar sampel dalam penelitian kedokteran dan kesehatan. Edisi ke-4. Jakarta: Epidemiologi Indonesia; 2016.
Fallo INY, Sidharta RA, Gunawan LS. Korelasi antara neutrophyl lymphocyte ratio dengan stadium kanker pada pasien kanker payudara. Biomedika. 2018;11(2):63-9.
Dirican A, Kucukzeybek BB, Alacacioglu A, Kucukzeybek Y, Erten C, Varol U, et al. Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer?. International Journal of Clinical Oncology. 2014;20(1):70-81.
Sadik CD, Kim ND, Luster AD. Neutrophils cascading their way to inflammation. Trends Immunol. 2011;32(10):452-60.
Azab B, Bhatt VR., Phookan J, Murukutla S, Kohn N, Terjanian T, et al. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Annals of Surgical Oncology. 2012;19(1):217-24.
Noh H, Eomm M , Han A. Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients. J Breast Cancer. 2013;16(1):55-9.
Ozyalvacli G, Yesil C, Kargi E, Kizildag B, Kilitci A, Yilmaz F . Diagnostic and prognostic importance of the neutrophil lymphocyte ratio in breast cancer. Asian Pacific Journal of Cancer Prevention. 2014;15(23):10363-6.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Medical Profession Journal of Lampung
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
